Home
Currency:USD
Language: en

ED RX Medications

0
You have no items in your shopping cart.

0

Currency: USD
Language: English

Welcome to our online pharmacy!

Vega Extra Cobra (sildenafil citrate)

Vega Extra Cobra (sildenafil citrate)

$ 1.02 per pill

Quick Overview

Selective Vegah Extra 120 Mg against PDE5 in vitro, its activity against PDE5 superior activity against other known PDE isoenzymes: PDE-6 — 10 times; PDE-1 more than 80 times; PDE-2, PDE-4, PDE-7 PDE–11 more than 700 times. Vegah Extra 120 Mg is 4000 times more selective for PDE-5 than PDE-3, which is crucial because PDE-3 is one of the key enzymes in the regulation of myocardial contractility.

Vega Extra Cobra® (Signature)

Vega Extra Cobra (Sildenafil citrate) 120 mg

Vega Extra Cobra
Sildenafil citrate
120 mg × 180 pills
$ 193.90 $ 183.95
$ 1.02 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 120 pills
$ 160.90 $ 151.95
$ 1.27 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 90 pills
$ 145.90 $ 137.95
$ 1.53 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 60 pills
$ 115.90 $ 109.95
$ 1.83 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 30 pills
$ 67.90 $ 63.95
$ 2.13 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 20 pills
$ 49.90 $ 46.95
$ 2.35 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 10 pills
$ 27.90 $ 25.95
$ 2.59 per pill
Buy

Information

The pharmacokinetics of Cobra 120 Vega Extra in the recommended dose range is linear.

Suction. After intake of Vegah Extra 130 is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Vegah Extra 120 Mg at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Vegah Extra 120 Mg 100 mg average Cmax free Vega Cobra in plasma men is about 18 ng/ml (38 nm). Cmax when taking Vegah Extra 120 Mg inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Vegah Extra 120 Mg is 105 l. the Association of Vega Cobra 120 Mg and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Vega Coin (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Cobra Vega 120 is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Vegah Extra 120 Mg, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Vegah Extra 120 Mg, and its activity against PDE-5 in vitro is about 50% of the activity of Vegah Extra 120 Mg. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Cobra Vega 120. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Vegah Extra 120 Mg is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Cobra Vega 120 Mg is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Clinical data

In a placebo-controlled cross-examination of patients with proven early age macular degeneration (n=9), Cobra 120 Vega Extra was well tolerated at a single dose of 100 mg. There were no clinically significant changes in vision evaluated by special visual tests (visual acuity, Amsler lattice, color perception, color simulation, Humphrey perimeter and photostress).

Efficiency. The efficacy and safety of Vegah Extra 120 Mg were evaluated in 21 randomized double-blind placebo-controlled studies lasting up to 6 months in 3000 patients from 19 to 87 years with erectile dysfunction of different etiology (organic, psychogenic or mixed). The efficacy of the drug was evaluated globally using an erection diary, an international erectile function index (validated questionnaire on the state of sexual function) and a partner survey.

The effectiveness of Vegah Extra 120 Mg, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated in all studies and confirmed in long-term studies lasting 1 year. In studies with the use of fixed-dose proportion of patients reporting that treatment improved their erections were 62% (dose of Vegah Extra 120 Mg 25 mg), 74% (dose Cobra Vega Extra Strong 120mg 50 mg) and 82% (dose Vega Extra Strong 120 100 mg) compared to 25% in the placebo group. Analysis of the international index of erectile function showed that in addition to improving erection treatment Signature Cobra Vega also increased the quality of orgasm, allowing to achieve satisfaction from sexual intercourse and overall satisfaction.

According to the generalized data, 59% of patients with diabetes, 43% of patients who underwent radical prostatectomy and 83% of patients with spinal cord injuries (against 16, 15 and 12% in the placebo group, respectively) were reported to have improved erection in the treatment of Sildenafil Vega Extra 130.

Pharmacokinetics

Influence of Vegah Extra 120 Mg on other drugs

Vega Extra Cobra 120 is a weak inhibitor of cytochrome P450 — 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 ISOENZYMES (IC50 >150 µmol). When taking Vegab Extra in recommended doses, its Cmax is about 1 µmol, so it is unlikely that Vegah Extra 120 Mg can affect the clearance of the substrates of these isoenzymes.

Vega Extra Cobra 120 increases the hypotensive effect of nitrates both with long-term use of the latter, and with their appointment for urgent indications. In this regard, the use of Cobra Vega Extra Strong 120mg in combination with nitrates or nitric oxide donators is contraindicated. While taking α-adrenoblocker doxazosin (4 and 8 mg) and Vegah Extra 120 Mg (25, 50 and 100 mg) in patients with benign prostate hyperplasia with stable hemodynamics, the average additional decrease in sad/dad in the supine position was 7/7, 9/5 and 8/4 mm Hg.article, respectively, while in the standing position — 6/6, 11/4 mmHg, and 4/5.art. respectively. Reported rare cases of symptomatic postural hypotension in such patients, manifested in the form of dizziness (without fainting). In some sensitive patients receiving α-blockers, simultaneous use of Vegah Extra 120 Mg can lead to symptomatic hypotension.

There were no signs of significant interaction with tolbutamide (250 mg) or warfarin (40 mg), which are metabolized by CYP2C9 isoenzyme.

Vega Extra Cobra 120 (100 mg) has no effect on the pharmacokinetics of the HIV protease inhibitor, saquinavir, which is a substrate of CYP3A4 isoenzyme, at its constant level in the blood.

The simultaneous use of Vegah Extra 120 Mg at equilibrium (80 mg 3 times a day) leads to an increase in the AUC and Cmax of bosentan (125 mg 2 times a day) by 49.8 and 42%, respectively.

Vegah Extra 120 Mg (50 mg) does not cause an additional increase in bleeding time when taking acetylsalicylic acid (150 mg).

Vegah Extra 120 Mg (50 mg) does not increase the hypotensive effect of alcohol in healthy volunteers with Cmax of alcohol in the blood on average 0.08‰ (80 mg/DL).

In patients with hypertension, no signs of interaction of Vegah Extra 120 Mg (100 mg) with amlodipine were found. The average additional reduction in blood PRESSURE in the supine position is 8 mm Hg.V. (systolic) and 7 mm Hg.V. (diastolic).

The use of Vega Extra Cobra 130 Mg in combination with antihypertensive agents does not lead to additional side effects.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Vegah Extra 120 Mg, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Vega Cobra therapy in case of sudden loss of vision and consult a doctor immediately.

Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Vegah Extra 120 Mg, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk. In patients with episodes of development PINZN with loss of vision in one eye receiving Vegah Extra 120 Mg is contraindicated (see "Contraindications").

A small number of patients with hereditary retinitis pigmentosa have genetically determined disorders of the PDE of the retina. Information about the safety of the drug Vega Extra Cobra 130 Mg in patients with retinitis pigmentosa absent, so these patients should not be used Cobra Vega Extra (see "Contraindications").



Vegah Extra 120 Indication

Reviews

Vega-extra87 out of100 with43 ratings
Vega-extraVega-extra is the most valuable business resource we have EVER purchased. Vega-extra should be nominated for service of the year. Great job, I will definitely be ordering again! Thanks guys, keep up the good work!Rating:88 out of100, 71Vega-extraThank you so much for your help.Rating:79 out of100, 71Vega-extraVega-extra is awesome! I would like to personally thank you for your outstanding product. It's the perfect solution for our business.Rating:78 out of100, 71Vega-extraNice work on your Vega-extra. We've used Vega-extra for the last five years.Rating:76 out of100, 71Vega-extraIf you want real marketing that works and effective implementation - Vega-extra's got you covered. It really saves me time and effort. Vega-extra is exactly what our business has been lacking. Vega-extra is the most valuable business resource we have EVER purchased.Rating:95 out of100, 71Vega-extraI made back the purchase price in just 48 hours!Rating:89 out of100, 71Vega-extraVega-extra is the most valuable business resource we have EVER purchased. We've seen amazing results already.Rating:100 out of100, 71Vega-extraThanks guys, keep up the good work!Rating:71 out of100, 71Vega-extraVega-extra should be nominated for service of the year. Buy this now. No matter where you go, Vega-extra is the coolest, most happening thing around!Rating:83 out of100, 71Vega-extraVega-extra is the most valuable business resource we have EVER purchased. It really saves me time and effort. Vega-extra is exactly what our business has been lacking. Just what I was looking for.Rating:88 out of100, 71Vega-extraI'd be lost without Vega-extra. Thank you so much for your help. Wow what great service, I love it!Rating:91 out of100, 71Vega-extraNice work on your Vega-extra.Rating:88 out of100, 71Vega-extraIt's incredible. I am completely blown away. It's really wonderful. It's exactly what I've been looking for.Rating:96 out of100, 71Vega-extraWithout Vega-extra, we would have gone bankrupt by now. Thanks guys, keep up the good work!Rating:81 out of100, 71Vega-extraI would like to personally thank you for your outstanding product.Rating:99 out of100, 71Vega-extraVega-extra is worth much more than I paid.Rating:94 out of100, 71Vega-extraWe're loving it. I would like to personally thank you for your outstanding product. It's incredible.Rating:100 out of100, 71Vega-extraVery easy to use. Thanks Vega-extra!Rating:98 out of100, 71Vega-extraThis is simply unbelievable! You won't regret it. We were treated like royalty.Rating:72 out of100, 71Vega-extraVega-extra has really helped our business. Vega-extra impressed me on multiple levels. You've saved our business!Rating:94 out of100, 71Vega-extraThanks to Vega-extra, we've just launched our 5th website! I would like to personally thank you for your outstanding product. This is simply unbelievable! I can't say enough about Vega-extra.Rating:81 out of100, 71Vega-extraI didn't even need training.Rating:100 out of100, 71Vega-extraVega-extra is the next killer app.Rating:98 out of100, 71Vega-extraNot able to tell you how happy I am with Vega-extra. The very best. Vega-extra is worth much more than I paid.Rating:73 out of100, 71Vega-extraI can't say enough about Vega-extra. Thanks Vega-extra! Since I invested in Vega-extra I made over 100,000 dollars profits.Rating:86 out of100, 71Vega-extraSince I invested in Vega-extra I made over 100,000 dollars profits.Rating:87 out of100, 71Vega-extraWow what great service, I love it! It's just amazing. I was amazed at the quality of Vega-extra.Rating:85 out of100, 71Vega-extraVery easy to use. Keep up the excellent work. I will let my mum know about this, she could really make use of Vega-extra! Vega-extra is the next killer app.Rating:80 out of100, 71Vega-extraVega-extra is the most valuable business resource we have EVER purchased.Rating:78 out of100, 71Vega-extraAfter using Vega-extra my business skyrocketed! This is simply unbelievable!Rating:91 out of100, 71Vega-extraVega-extra is the next killer app. Thank you so much for your help. Vega-extra is the next killer app.Rating:91 out of100, 71Vega-extraThanks for the great service. I don't always clop, but when I do, it's because of Vega-extra. We've seen amazing results already.Rating:83 out of100, 71Vega-extraI was amazed at the quality of Vega-extra.Rating:83 out of100, 71Vega-extraBest. Product. Ever!Rating:97 out of100, 71Vega-extraI STRONGLY recommend Vega-extra to EVERYONE interested in running a successful online business! This is simply unbelievable! Vega-extra is the most valuable business resource we have EVER purchased. Thank you so much for your help.Rating:95 out of100, 71Vega-extraI would also like to say thank you to all your staff.Rating:93 out of100, 71Vega-extraVega-extra should be nominated for service of the year. Buy this now. No matter where you go, Vega-extra is the coolest, most happening thing around!Rating:94 out of100, 71Vega-extraNot able to tell you how happy I am with Vega-extra. We've used Vega-extra for the last five years.Rating:71 out of100, 71Vega-extraReally good. The service was excellent. Thanks Vega-extra!Rating:95 out of100, 71Vega-extraDefinitely worth the investment. I couldn't have asked for more than this.Rating:90 out of100, 71Vega-extraJust what I was looking for. It really saves me time and effort. Vega-extra is exactly what our business has been lacking. Man, this thing is getting better and better as I learn more about it. If you want real marketing that works and effective implementation - Vega-extra's got you covered.Rating:76 out of100, 71Vega-extraGreat job, I will definitely be ordering again!Rating:71 out of100, 71Vega-extraNo matter where you go, Vega-extra is the coolest, most happening thing around! It fits our needs perfectly.Rating:96 out of100, 71

Our bestsellers