Home
Currency:USD
Language: en

ED RX Medications

0
You have no items in your shopping cart.

0

Currency: USD
Language: English

Welcome to our online pharmacy!

Vega Extra Cobra (sildenafil citrate)

Vega Extra Cobra (sildenafil citrate)

$ 1.02 per pill

Quick Overview

Vega Extra Strong 120 enhances the antiplatelet effect of sodium nitroprusside, a nitric oxide donator, on human platelets in vitro. Data on the safety of Vega Extra Strong 120 in patients with a tendency to bleeding or exacerbation of gastric ulcer and duodenal ulcer are not available, so the drug Vega Extra Strong 120 in these patients should be used with caution (see With caution).

Vega Extra Cobra® (Signature)

Vega Extra Cobra (Sildenafil citrate) 120 mg

Vega Extra Cobra
Sildenafil citrate
120 mg × 180 pills
$ 193.90 $ 183.95
$ 1.02 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 120 pills
$ 160.90 $ 151.95
$ 1.27 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 90 pills
$ 145.90 $ 137.95
$ 1.53 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 60 pills
$ 115.90 $ 109.95
$ 1.83 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 30 pills
$ 67.90 $ 63.95
$ 2.13 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 20 pills
$ 49.90 $ 46.95
$ 2.35 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 10 pills
$ 27.90 $ 25.95
$ 2.59 per pill
Buy

Information

Influence of Vega Extra Strong 120 on other drugs

Vega Extra Strong 120 is a weak inhibitor of cytochrome P450 — 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 ISOENZYMES (IC50 >150 µmol). When taking Vega Extra Strong 120 in recommended doses, its Cmax is about 1 µmol, so it is unlikely that Signature Cobra Vega can affect the clearance of the substrates of these isoenzymes.

Vega Extra 120 Mg increases the hypotensive effect of nitrates both with long-term use of the latter, and with their appointment for urgent indications. In this regard, the use of Vega Extra Strong 120 in combination with nitrates or nitric oxide donators is contraindicated. While taking α-adrenoblocker doxazosin (4 and 8 mg) and Vega Extra Strong 120 (25, 50 and 100 mg) in patients with benign prostate hyperplasia with stable hemodynamics, the average additional decrease in sad/dad in the supine position was 7/7, 9/5 and 8/4 mm Hg.article, respectively, while in the standing position — 6/6, 11/4 mmHg, and 4/5.art. respectively. Reported rare cases of symptomatic postural hypotension in such patients, manifested in the form of dizziness (without fainting). In some sensitive patients receiving α-blockers, simultaneous use of Vegah Extra 120 Indication can lead to symptomatic hypotension.

There were no signs of significant interaction with tolbutamide (250 mg) or warfarin (40 mg), which are metabolized by CYP2C9 isoenzyme.

Vega Extra Strong 120 (100 mg) has no effect on the pharmacokinetics of the HIV protease inhibitor, saquinavir, which is a substrate of CYP3A4 isoenzyme, at its constant level in the blood.

The simultaneous use of Vega Extra Strong 120 at equilibrium (80 mg 3 times a day) leads to an increase in the AUC and Cmax of bosentan (125 mg 2 times a day) by 49.8 and 42%, respectively.

Sildenafil Vega Extra 120 (50 mg) does not cause an additional increase in bleeding time when taking acetylsalicylic acid (150 mg).

Vega Extra Strong 120 (50 mg) does not increase the hypotensive effect of alcohol in healthy volunteers with Cmax of alcohol in the blood on average 0.08‰ (80 mg/DL).

In patients with hypertension, no signs of interaction of Cobra Vega 120 Mg (100 mg) with amlodipine were found. The average additional reduction in blood PRESSURE in the supine position is 8 mm Hg.V. (systolic) and 7 mm Hg.V. (diastolic).

The use of Vegal Extra in combination with antihypertensive agents does not lead to additional side effects.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Sildenafil Tablets Vega Extra Cobra, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Vegah Extra 120 Mg therapy in case of sudden loss of vision and consult a doctor immediately.

Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Vega Extra 120, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk. In patients with episodes of development PINZN with loss of vision in one eye receiving Vega Extra Strong 120 is contraindicated (see "Contraindications").

A small number of patients with hereditary retinitis pigmentosa have genetically determined disorders of the PDE of the retina. Information about the safety of the drug Vega Extra Strong 120 in patients with retinitis pigmentosa absent, so these patients should not be used Vega Extra Strong 120 (see "Contraindications").

The pharmacokinetics of Vegah Extra 120 Indication in the recommended dose range is linear.

Suction. After intake of Vega Extra Strong 120 is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Vega Extra Strong 120 at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Vegal Extra 100 mg average Cmax free Vega Extra Strong 120 in plasma men is about 18 ng/ml (38 nm). Cmax when taking Vega Extra Strong 120 inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Vega Visa is 105 l. the Association of Vega Extra Strong 120 and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Vega Extra 120 (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Vega Extra Strong 120 is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Vega Extra Strong 120, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Vega Coin, and its activity against PDE-5 in vitro is about 50% of the activity of Vega Extra Strong 120. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Vega Extra Strong 120. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Vega Extra Strong 120 is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Vega Extra Strong 120 is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Cardiovascular complications

During the post-marketing use of Sildenafil Vega Extra 120 for the treatment of erectile dysfunction, adverse events such as severe cardiovascular complications (including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, hemorrhagic stroke, transient ischemic attack, hypertension and hypotension) were reported, which had a temporary connection with the use of Vega Cobra 120 Mg. Most of these patients, but not all of them, had risk factors for cardiovascular complications. Many of these adverse events were observed shortly after sexual activity, and some were observed after taking Extra Vega without subsequent sexual activity. It is not possible to establish a direct link between the reported adverse events and those or other factors.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Vega Extra Strong 120, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk of developing NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Sildenafil Vega Extra 120 therapy in case of sudden loss of vision and consult a doctor immediately. Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Sildenafil Vega Extra 130 Mg, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk.

When using the drug Sildenafil Vega Extra 120 in doses exceeding the recommended, adverse events were similar to those noted above, but usually more common.

*Side effects identified during post-marketing studies.

Interaction

Effect of other drugs on the pharmacokinetics of Extra Vega

The metabolism of Vega Extra Strong 120 occurs mainly under the action of CYP3A4 isoenzyme (main pathway), so inhibitors of this isoenzyme can reduce the clearance of Vega Extra Strong 120, and inducers, respectively, increase the clearance of Vega Extra Cobra 130 Mg. A decrease in the clearance of Sildenafil Vega Extra 130 Mg with simultaneous use of inhibitors of CYP3A4 isoenzyme (ketoconazole, erythromycin, cimetidine).

Cimetidine (800 mg), a nonspecific inhibitor of CYP3A4 isoenzyme, when taken together with Vega Pills (50 mg) causes an increase in the concentration of Cobra Vega Extra Strong 120 Mg in plasma by 56%.

A single dose of 100 mg of Vega Extra Strong 120 together with erythromycin (500 mg/day 2 times a day for 5 days), a moderate inhibitor of CYP3A4 isoenzyme, while achieving a constant concentration of erythromycin in the blood, leads to an increase in the AUC of Vega Extra Strong 120 by 182%.

When co-administered Vega Extra Strong 120 (once 100 mg) and saquinavir (1200 mg/day 3 times daily), an inhibitor of HIV protease and of CYP3A4, on the background to achieve a constant concentration of saquinavir in the blood, Cmax of Vega Extra 120 was increased by 140% and the AUC increased by 210%.

Stronger inhibitors of CYP3A4 isoenzyme, such as ketoconazole and Itraconazole, can cause more pronounced changes in the pharmacokinetics of Cobra Vega Extra Strong 120 Mg.

The simultaneous use of Vega Extra Strong 120 (100 mg once) and ritonavir (500 mg 2 times a day), an inhibitor of HIV protease and a strong inhibitor of cytochrome P450, on the background to achieve a constant concentration of ritonavir in the blood leads to an increase in Cmax of Vega Extra Strong 120 by 300% (4 times), a AUC by 1000% (11-fold). After 24 h, the concentration of Vega Extra Strong 120 in blood plasma is about 200 ng/ml (after a single application of one Vega Extra Strong 120 — 5 ng/ml). This is consistent with the ritonavir effect on a wide range of cytochrome P450 substrates. Vega Extra Strong 120 does not affect the pharmacokinetics of ritonavir. Given these data, the simultaneous reception of ritonavir and Vega Extra Strong 120 is not recommended. In any case, the maximum dose of Vega Extra Strong 120 under any circumstances should not exceed 25 mg for 48 hours. If Vega Extra Strong 120 is taken in the recommended doses, patients receiving strong inhibitors of CYP3A4 isoenzyme at the same time, then Cmax free Vega Extra Strong 120 does not exceed 200 nm, and the drug is well tolerated.

Single administration of antacid (magnesium hydroxide/aluminum hydroxide) does not affect the bioavailability of Vega Extra Strong 120.

Studies involving healthy volunteers with simultaneous use of endothelin receptor antagonist, bosentan (CYP3A4 isoenzyme inducer (moderate), CYP2C9, and possibly CYP2C19) in Css (125 mg 2 times a day) and Vegah Cobra in Css (80 mg 3 times a day) showed a decrease in AUC and Cmax Vega Extra Strong 120 by 62.6 and 52.4%, respectively. Vega Extra Strong 120 increased the AUC and Cmax of bosentan by 49.8 and 42%, respectively.

It is assumed that the simultaneous use of Vega Extra Strong 120 with powerful inducers of CYP3A4 isoenzyme, such as rifampicin, can lead to a greater decrease in the concentration of Cobra 120 Vega Extra in blood plasma.

CYP2D6 isoenzyme inhibitors (SSRIs, tricyclic antidepressants), thiazide and thiazide-like diuretics, ACE inhibitors and calcium antagonists have no effect on the pharmacokinetics of Vega Extra Strong 120.

Azithromycin (500 mg/day for 3 days) has no effect on AUC, Cmax, Tmax, excretion rate constant and T1/2 Vegab Extra or its main circulating metabolite.



Sildenafil Vega Extra 120

Reviews

Vega-extra85 out of100 with43 ratings
Vega-extraBuy this now. The service was excellent.Rating:82 out of100, 70Vega-extraBuy this now.Rating:85 out of100, 70Vega-extraYou've saved our business! Vega-extra impressed me on multiple levels. Man, this thing is getting better and better as I learn more about it. Thanks Vega-extra!Rating:83 out of100, 70Vega-extraThis is simply unbelievable! You won't regret it. We were treated like royalty.Rating:70 out of100, 70Vega-extraI use Vega-extra often. Vega-extra has got everything I need.Rating:83 out of100, 70Vega-extraIt's just amazing. I made back the purchase price in just 48 hours! It's incredible. The best on the net!Rating:94 out of100, 70Vega-extraVega-extra impressed me on multiple levels.Rating:73 out of100, 70Vega-extra Vega-extra should be nominated for service of the year. I would gladly pay over 600 dollars for Vega-extra. Vega-extra is great.Rating:81 out of100, 70Vega-extraIt's incredible. Thank you so much for your help. If you aren't sure, always go for Vega-extra.Rating:99 out of100, 70Vega-extraThanks guys, keep up the good work! Really good. I would like to personally thank you for your outstanding product. We've used Vega-extra for the last five years.Rating:80 out of100, 70Vega-extraNot able to tell you how happy I am with Vega-extra. Vega-extra is exactly what our business has been lacking. Man, this thing is getting better and better as I learn more about it. If you want real marketing that works and effective implementation - Vega-extra's got you covered.Rating:82 out of100, 70Vega-extraGreat job, I will definitely be ordering again! Vega-extra is exactly what our business has been lacking.Rating:83 out of100, 70Vega-extraThanks guys, keep up the good work! I don't know what else to say. Keep up the excellent work.Rating:71 out of100, 70Vega-extraVega-extra saved my business. The service was excellent.Rating:100 out of100, 70Vega-extraDude, your stuff is the bomb!Rating:82 out of100, 70Vega-extraGreat job, I will definitely be ordering again! It really saves me time and effort. Vega-extra is exactly what our business has been lacking.Rating:76 out of100, 70Vega-extraThe very best. Vega-extra is exactly what our business has been lacking. I would like to personally thank you for your outstanding product.Rating:80 out of100, 70Vega-extraWe can't understand how we've been living without Vega-extra. Best. Product. Ever! I am so pleased with this product.Rating:72 out of100, 70Vega-extraVega-extra did exactly what you said it does. Thank You! I would like to personally thank you for your outstanding product. Just what I was looking for.Rating:96 out of100, 70Vega-extraI wish I would have thought of it first.Rating:91 out of100, 70Vega-extraNo matter where you go, Vega-extra is the coolest, most happening thing around! Without Vega-extra, we would have gone bankrupt by now. It's exactly what I've been looking for.Rating:89 out of100, 70Vega-extraWe have no regrets!Rating:88 out of100, 70Vega-extraI was amazed at the quality of Vega-extra. If you want real marketing that works and effective implementation - Vega-extra's got you covered.Rating:89 out of100, 70Vega-extraI am completely blown away. Vega-extra is worth much more than I paid.Rating:77 out of100, 70Vega-extraVery easy to use. I love Vega-extra. Thank You!Rating:89 out of100, 70Vega-extraIt's just amazing. Since I invested in Vega-extra I made over 100,000 dollars profits. We were treated like royalty. I use Vega-extra often.Rating:86 out of100, 70Vega-extraNeedless to say we are extremely satisfied with the results. Thank you for making it painless, pleasant and most of all hassle free! Vega-extra is exactly what our business has been lacking.Rating:91 out of100, 70Vega-extraI have gotten at least 50 times the value from Vega-extra.Rating:89 out of100, 70Vega-extraThanks for the great service.Rating:84 out of100, 70Vega-extraWow what great service, I love it! It's just amazing. I was amazed at the quality of Vega-extra.Rating:79 out of100, 70Vega-extraVega-extra is the next killer app.Rating:96 out of100, 70Vega-extraVega-extra was the best investment I ever made. Keep up the excellent work. Vega-extra is the most valuable business resource we have EVER purchased.Rating:88 out of100, 70Vega-extraDude, your stuff is the bomb! Great job, I will definitely be ordering again! Vega-extra is the real deal!Rating:100 out of100, 70Vega-extraI'd be lost without Vega-extra. Nice work on your Vega-extra. It's really wonderful. I like Vega-extra more and more each day because it makes my life a lot easier.Rating:84 out of100, 70Vega-extraIt's incredible. I will recommend you to my colleagues. Wow what great service, I love it!Rating:82 out of100, 70Vega-extraAbsolutely wonderful! Dude, your stuff is the bomb!Rating:80 out of100, 70Vega-extraBest. Product. Ever! Your company is truly upstanding and is behind its product 100%.Rating:81 out of100, 70Vega-extraThe best on the net! It's all good. The very best.Rating:97 out of100, 70Vega-extraVega-extra is the most valuable business resource we have EVER purchased. Since I invested in Vega-extra I made over 100,000 dollars profits.Rating:87 out of100, 70Vega-extraVega-extra is both attractive and highly adaptable. Vega-extra is worth much more than I paid.Rating:92 out of100, 70Vega-extraI can't say enough about Vega-extra. Vega-extra is exactly what our business has been lacking. Vega-extra is exactly what our business has been lacking. I'd be lost without Vega-extra.Rating:72 out of100, 70Vega-extraIf you want real marketing that works and effective implementation - Vega-extra's got you covered. If you want real marketing that works and effective implementation - Vega-extra's got you covered.Rating:94 out of100, 70Vega-extraReally good. Vega-extra is the most valuable business resource we have EVER purchased. I would be lost without Vega-extra. Vega-extra is both attractive and highly adaptable.Rating:80 out of100, 70

Our bestsellers