Home
Currency:USD
Language: en

ED RX Medications

0
You have no items in your shopping cart.

0

Currency: USD
Language: English

Welcome to our online pharmacy!

Vega Extra Cobra (sildenafil citrate)

Vega Extra Cobra (sildenafil citrate)

$ 1.02 per pill

Quick Overview

Selective Vegah Extra 130 against PDE5 in vitro, its activity against PDE5 superior activity against other known PDE isoenzymes: PDE-6 — 10 times; PDE-1 more than 80 times; PDE-2, PDE-4, PDE-7 PDE–11 more than 700 times. Vegah Extra 130 is 4000 times more selective for PDE-5 than PDE-3, which is crucial because PDE-3 is one of the key enzymes in the regulation of myocardial contractility.

Vega Extra Cobra® (Signature)

Vega Extra Cobra (Sildenafil citrate) 120 mg

Vega Extra Cobra
Sildenafil citrate
120 mg × 180 pills
$ 193.90 $ 183.95
$ 1.02 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 120 pills
$ 160.90 $ 151.95
$ 1.27 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 90 pills
$ 145.90 $ 137.95
$ 1.53 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 60 pills
$ 115.90 $ 109.95
$ 1.83 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 30 pills
$ 67.90 $ 63.95
$ 2.13 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 20 pills
$ 49.90 $ 46.95
$ 2.35 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 10 pills
$ 27.90 $ 25.95
$ 2.59 per pill
Buy

Information

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Vega Coin, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Sildenafil Tablets Vega Extra Cobra therapy in case of sudden loss of vision and consult a doctor immediately.

Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Vega Extra Cobra 120, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk. In patients with episodes of development PINZN with loss of vision in one eye receiving Vegal Extra is contraindicated (see "Contraindications").

A small number of patients with hereditary retinitis pigmentosa have genetically determined disorders of the PDE of the retina. Information about the safety of the drug Vega Extra 120 Mg in patients with retinitis pigmentosa absent, so these patients should not be used Sildenafil Tablets Vega Extra Cobra (see "Contraindications").

Vega Extra is a potent selective inhibitor of cGMP-specific PDE-5.



Mechanism of action

The implementation of the physiological mechanism of erection is associated with the release of nitric oxide (NO) in the cavernous body during sexual stimulation. This, in turn, leads to an increase in the level of cGMP, the subsequent relaxation of smooth muscle tissue of the cavernous body and an increase in blood flow.

Vega Extra 120 Mg does not have a direct relaxing effect on the isolated cavernous human body, but enhances the effect of nitric oxide by inhibiting PDE-5, which is responsible for the disintegration of cGMP.

Selective Sildenafil Vega Extra 120 against PDE5 in vitro, its activity against PDE5 superior activity against other known PDE isoenzymes: PDE-6 — 10 times; PDE-1 more than 80 times; PDE-2, PDE-4, PDE-7 PDE–11 more than 700 times. Sildenafil Vega Extra 120 is 4000 times more selective for PDE-5 than PDE-3, which is crucial because PDE-3 is one of the key enzymes in the regulation of myocardial contractility.

A prerequisite for the effectiveness of Vegah Extra 120 Indication is sexual stimulation.

Vega Extra 120 Mg restores impaired erectile function in conditions of sexual stimulation by increasing blood flow to the cavernous bodies of the penis.

Hearing impairment

Some post-marketing and clinical studies have reported cases of sudden hearing loss or impairment associated with the use of all PDE-5 inhibitors, including Vega Extra 120 Mg. Most of these patients had risk factors for sudden impairment or hearing loss. There is no causal relationship between the use of PDE-5 inhibitors and sudden hearing impairment or hearing loss. In case of sudden hearing impairment or hearing loss while taking Vega Extra Cobra 120, consult a doctor immediately.

Bleedings

Vegah Cobra enhances the antiplatelet effect of sodium nitroprusside, a nitric oxide donator, on human platelets in vitro. Data on the safety of Vega Extra 120 Mg in patients with a tendency to bleeding or exacerbation of gastric ulcer and duodenal ulcer are not available, so the drug Cobra Vega Extra in these patients should be used with caution (see With caution).

The incidence of nosebleeds in patients with pulmonary hypertension associated with diffuse connective tissue diseases was higher (Sildenafil Tablets Vega Extra Cobra — 12.9%, placebo — 0%) than in patients with primary pulmonary arterial hypertension (Vegah Extra 130 — 3%, placebo — 2.4%). Patients receiving Vegal Extra in combination with an antagonist of vitamin K, the frequency of nasal bleeding was higher (8.8 percent) than patients who were not taking an antagonist of vitamin K (1.7 percent).

Use in conjunction with other means for the treatment of erectile dysfunction

The safety and efficacy of Vega Extra 120 Mg together with other PDE-5 inhibitors or other drugs for the treatment of pulmonary hypertension containing Vega Extra 120 Mg (eg, Revatsio®), or other means for the treatment of erection disorders have not been studied, so the use of such combinations is not recommended (see "Contraindications").

Influence on the ability to drive and mechanisms. In patients receiving Vega Extra 120 Mg any negative effect on the ability to drive a car or other means was not observed. However, since when taking Vega Pills may develop dizziness, lowering blood PRESSURE, the development of chromatopsia, blurred vision, etc. side effects, care should be taken when driving and doing other potentially dangerous activities that require increased concentration and speed of psychomotor reactions. Also, you should be careful about the individual action of the drug in these situations, especially at the beginning of treatment and when changing the dosage regimen.

Cardiovascular complications

During the post-marketing use of Vega Extra 120 Mg for the treatment of erectile dysfunction, adverse events such as severe cardiovascular complications (including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, hemorrhagic stroke, transient ischemic attack, hypertension and hypotension) were reported, which had a temporary connection with the use of Vega Extra 120 Mg. Most of these patients, but not all of them, had risk factors for cardiovascular complications. Many of these adverse events were observed shortly after sexual activity, and some were observed after taking Vega Extra 120 Mg without subsequent sexual activity. It is not possible to establish a direct link between the reported adverse events and those or other factors.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Vega 120 Mg, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk of developing NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Vega Extra Strong 120 therapy in case of sudden loss of vision and consult a doctor immediately. Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Sildenafil Vega Extra 130 Mg Cobra, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk.

When using the drug Vega Extra 120 Mg in doses exceeding the recommended, adverse events were similar to those noted above, but usually more common.

*Side effects identified during post-marketing studies.

Interaction

Effect of other drugs on the pharmacokinetics of Vegah Extra 120 Indication

The metabolism of Vega Extra Cobra occurs mainly under the action of CYP3A4 isoenzyme (main pathway), so inhibitors of this isoenzyme can reduce the clearance of Vega Extra, and inducers, respectively, increase the clearance of Sildenafil Vega Extra 130 Mg. A decrease in the clearance of Vega Extra 120 Mg with simultaneous use of inhibitors of CYP3A4 isoenzyme (ketoconazole, erythromycin, cimetidine).

Cimetidine (800 mg), a nonspecific inhibitor of CYP3A4 isoenzyme, when taken together with Sildenafil Vega Extra 130 (50 mg) causes an increase in the concentration of Cobra Vega 120 in plasma by 56%.

A single dose of 100 mg of Vega Extra 120 Mg together with erythromycin (500 mg/day 2 times a day for 5 days), a moderate inhibitor of CYP3A4 isoenzyme, while achieving a constant concentration of erythromycin in the blood, leads to an increase in the AUC of Vega Pills by 182%.

When co-administered Vega Extra 120 Mg (once 100 mg) and saquinavir (1200 mg/day 3 times daily), an inhibitor of HIV protease and of CYP3A4, on the background to achieve a constant concentration of saquinavir in the blood, Cmax of Vega Extra Cobra 120 was increased by 140% and the AUC increased by 210%.

Stronger inhibitors of CYP3A4 isoenzyme, such as ketoconazole and Itraconazole, can cause more pronounced changes in the pharmacokinetics of Vega Cobra 120.

The simultaneous use of Vega Extra 120 Mg (100 mg once) and ritonavir (500 mg 2 times a day), an inhibitor of HIV protease and a strong inhibitor of cytochrome P450, on the background to achieve a constant concentration of ritonavir in the blood leads to an increase in Cmax of Vega Extra 120 Mg by 300% (4 times), a AUC by 1000% (11-fold). After 24 h, the concentration of Vega Extra Cobra 130 Mg in blood plasma is about 200 ng/ml (after a single application of one Vega Extra 120 Mg — 5 ng/ml). This is consistent with the ritonavir effect on a wide range of cytochrome P450 substrates. Vega Pills does not affect the pharmacokinetics of ritonavir. Given these data, the simultaneous reception of ritonavir and Vega Extra 120 Mg is not recommended. In any case, the maximum dose of Sildenafil Vega Extra 120 under any circumstances should not exceed 25 mg for 48 hours. If Vega Extra 120 Mg is taken in the recommended doses, patients receiving strong inhibitors of CYP3A4 isoenzyme at the same time, then Cmax free Vega Extra 120 Mg does not exceed 200 nm, and the drug is well tolerated.

Single administration of antacid (magnesium hydroxide/aluminum hydroxide) does not affect the bioavailability of Vegah Extra 130.

Studies involving healthy volunteers with simultaneous use of endothelin receptor antagonist, bosentan (CYP3A4 isoenzyme inducer (moderate), CYP2C9, and possibly CYP2C19) in Css (125 mg 2 times a day) and Vegab Extra in Css (80 mg 3 times a day) showed a decrease in AUC and Cmax Vega Visa by 62.6 and 52.4%, respectively. Sildenafil Tablets Vegah Extra Cobra increased the AUC and Cmax of bosentan by 49.8 and 42%, respectively.

It is assumed that the simultaneous use of Vega Extra Cobra 130 Mg with powerful inducers of CYP3A4 isoenzyme, such as rifampicin, can lead to a greater decrease in the concentration of Sildenafil Tablets Vega Extra Cobra in blood plasma.

CYP2D6 isoenzyme inhibitors (SSRIs, tricyclic antidepressants), thiazide and thiazide-like diuretics, ACE inhibitors and calcium antagonists have no effect on the pharmacokinetics of Vega Extra 120 Mg.

Azithromycin (500 mg/day for 3 days) has no effect on AUC, Cmax, Tmax, excretion rate constant and T1/2 Vega Extra 120 Mg or its main circulating metabolite.



Vegah Extra 130

Reviews

Vega-extra85 out of100 with36 ratings
Vega-extraI'm good to go. I use Vega-extra often. The service was excellent. I can't say enough about Vega-extra.Rating:95 out of100, 70Vega-extraThanks Vega-extra!Rating:76 out of100, 70Vega-extraGreat job, I will definitely be ordering again! It really saves me time and effort. Vega-extra is exactly what our business has been lacking.Rating:72 out of100, 70Vega-extraWe're loving it. Not able to tell you how happy I am with Vega-extra.Rating:70 out of100, 70Vega-extraI made back the purchase price in just 48 hours! I love Vega-extra.Rating:81 out of100, 70Vega-extraThis is simply unbelievable! You won't regret it. We were treated like royalty.Rating:86 out of100, 70Vega-extraVega-extra is great. It really saves me time and effort. Vega-extra is exactly what our business has been lacking.Rating:88 out of100, 70Vega-extraI am completely blown away. Vega-extra has really helped our business. I didn't even need training.Rating:81 out of100, 70Vega-extraVega-extra was worth a fortune to my company.Rating:94 out of100, 70Vega-extraI have gotten at least 50 times the value from Vega-extra. I would also like to say thank you to all your staff.Rating:81 out of100, 70Vega-extraWe have no regrets!Rating:70 out of100, 70Vega-extraGreat job, I will definitely be ordering again! Vega-extra is both attractive and highly adaptable. I will let my mum know about this, she could really make use of Vega-extra!Rating:99 out of100, 70Vega-extraThis is simply unbelievable! Vega-extra is great.Rating:81 out of100, 70Vega-extraNo matter where you go, Vega-extra is the coolest, most happening thing around! Without Vega-extra, we would have gone bankrupt by now. It's exactly what I've been looking for.Rating:98 out of100, 70Vega-extraWe've used Vega-extra for the last five years. Wow what great service, I love it! Vega-extra has really helped our business.Rating:88 out of100, 70Vega-extraThis is simply unbelievable! Vega-extra has got everything I need. Really good. I couldn't have asked for more than this.Rating:86 out of100, 70Vega-extraThe very best. Vega-extra is exactly what our business has been lacking. I would like to personally thank you for your outstanding product.Rating:93 out of100, 70Vega-extraI don't always clop, but when I do, it's because of Vega-extra. It fits our needs perfectly. Keep up the excellent work.Rating:80 out of100, 70Vega-extraWe've seen amazing results already. It's exactly what I've been looking for. It really saves me time and effort. Vega-extra is exactly what our business has been lacking. I didn't even need training.Rating:70 out of100, 70Vega-extraThank you so much for your help. You've saved our business! It's just amazing. I am so pleased with this product.Rating:80 out of100, 70Vega-extraI'm good to go. I have gotten at least 50 times the value from Vega-extra. I would like to personally thank you for your outstanding product.Rating:80 out of100, 70Vega-extraWow what great service, I love it! It's all good. You guys rock!Rating:86 out of100, 70Vega-extraWe have no regrets! If you want real marketing that works and effective implementation - Vega-extra's got you covered. Vega-extra is awesome!Rating:91 out of100, 70Vega-extraIt's just amazing. Buy this now. Man, this thing is getting better and better as I learn more about it.Rating:77 out of100, 70Vega-extraGreat job, I will definitely be ordering again! Thanks Vega-extra! I am so pleased with this product. Wow what great service, I love it!Rating:93 out of100, 70Vega-extra Vega-extra is exactly what our business has been lacking.Rating:91 out of100, 70Vega-extraI'd be lost without Vega-extra. Nice work on your Vega-extra. It's really wonderful. I like Vega-extra more and more each day because it makes my life a lot easier.Rating:91 out of100, 70Vega-extraI would like to personally thank you for your outstanding product. Vega-extra saved my business. No matter where you go, Vega-extra is the coolest, most happening thing around!Rating:80 out of100, 70Vega-extraThis is simply unbelievable! Vega-extra has got everything I need. Really good. I couldn't have asked for more than this.Rating:91 out of100, 70Vega-extraIt's just amazing. Buy this now. Man, this thing is getting better and better as I learn more about it.Rating:99 out of100, 70Vega-extraVega-extra is the most valuable business resource we have EVER purchased. Absolutely wonderful!Rating:93 out of100, 70Vega-extraThis is simply unbelievable! You won't regret it. We were treated like royalty.Rating:97 out of100, 70Vega-extraI love your system. Vega-extra is awesome!Rating:96 out of100, 70Vega-extraJust what I was looking for. I'd be lost without Vega-extra. I just can't get enough of Vega-extra. I want to get a T-Shirt with Vega-extra on it so I can show it off to everyone.Rating:71 out of100, 70Vega-extraI STRONGLY recommend Vega-extra to EVERYONE interested in running a successful online business! We can't understand how we've been living without Vega-extra. Very easy to use. I love Vega-extra.Rating:75 out of100, 70Vega-extraVega-extra did exactly what you said it does. I love your system.Rating:72 out of100, 70

Our bestsellers