Home
Currency:USD
Language: en

ED RX Medications

0
You have no items in your shopping cart.

0

Currency: USD
Language: English

Welcome to our online pharmacy!

Vega Extra Cobra (sildenafil citrate)

Vega Extra Cobra (sildenafil citrate)

$ 1.02 per pill

Quick Overview

The implementation of the physiological mechanism of erection is associated with the release of nitric oxide (NO) in the cavernous body during sexual stimulation. This, in turn, leads to an increase in the level of cGMP, the subsequent relaxation of smooth muscle tissue of the cavernous body and an increase in blood flow.

Vega Extra Cobra® (Signature)

Vega Extra Cobra (Sildenafil citrate) 120 mg

Vega Extra Cobra
Sildenafil citrate
120 mg × 180 pills
$ 193.90 $ 183.95
$ 1.02 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 120 pills
$ 160.90 $ 151.95
$ 1.27 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 90 pills
$ 145.90 $ 137.95
$ 1.53 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 60 pills
$ 115.90 $ 109.95
$ 1.83 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 30 pills
$ 67.90 $ 63.95
$ 2.13 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 20 pills
$ 49.90 $ 46.95
$ 2.35 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 10 pills
$ 27.90 $ 25.95
$ 2.59 per pill
Buy

Information

Clinical data

In a placebo-controlled cross-examination of patients with proven early age macular degeneration (n=9), Vega Extra Cobra 130 Mg was well tolerated at a single dose of 100 mg. There were no clinically significant changes in vision evaluated by special visual tests (visual acuity, Amsler lattice, color perception, color simulation, Humphrey perimeter and photostress).

Efficiency. The efficacy and safety of Vega Extra Cobra 130 Mg were evaluated in 21 randomized double-blind placebo-controlled studies lasting up to 6 months in 3000 patients from 19 to 87 years with erectile dysfunction of different etiology (organic, psychogenic or mixed). The efficacy of the drug was evaluated globally using an erection diary, an international erectile function index (validated questionnaire on the state of sexual function) and a partner survey.

The effectiveness of Vega Extra, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated in all studies and confirmed in long-term studies lasting 1 year. In studies with the use of fixed-dose proportion of patients reporting that treatment improved their erections were 62% (dose of Vega Extra Strong 120 25 mg), 74% (dose Vega Extra Cobra 120 50 mg) and 82% (dose Vega Extra Cobra 100 mg) compared to 25% in the placebo group. Analysis of the international index of erectile function showed that in addition to improving erection treatment Vegah Extra 130 also increased the quality of orgasm, allowing to achieve satisfaction from sexual intercourse and overall satisfaction.

According to the generalized data, 59% of patients with diabetes, 43% of patients who underwent radical prostatectomy and 83% of patients with spinal cord injuries (against 16, 15 and 12% in the placebo group, respectively) were reported to have improved erection in the treatment of Vega Extra Cobra 130 Mg.

Pharmacokinetics

Cardiovascular complications

During the post-marketing use of Vega 120 Mg for the treatment of erectile dysfunction, adverse events such as severe cardiovascular complications (including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, hemorrhagic stroke, transient ischemic attack, hypertension and hypotension) were reported, which had a temporary connection with the use of Vega Extra Cobra 130 Mg. Most of these patients, but not all of them, had risk factors for cardiovascular complications. Many of these adverse events were observed shortly after sexual activity, and some were observed after taking Cobra 120 Vega Extra without subsequent sexual activity. It is not possible to establish a direct link between the reported adverse events and those or other factors.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Vega Extra Cobra 130 Mg, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk of developing NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Vega Cobra 120 Mg therapy in case of sudden loss of vision and consult a doctor immediately. Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Cobra Vega Extra, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk.

When using the drug Vega Extra Cobra 130 Mg in doses exceeding the recommended, adverse events were similar to those noted above, but usually more common.

*Side effects identified during post-marketing studies.

Interaction

Effect of other drugs on the pharmacokinetics of Vega Extra Cobra 130 Mg

The metabolism of Cobra Vega occurs mainly under the action of CYP3A4 isoenzyme (main pathway), so inhibitors of this isoenzyme can reduce the clearance of Vegah Extra 130, and inducers, respectively, increase the clearance of Vegal Extra. A decrease in the clearance of Vega Extra Cobra 130 Mg with simultaneous use of inhibitors of CYP3A4 isoenzyme (ketoconazole, erythromycin, cimetidine).

Cimetidine (800 mg), a nonspecific inhibitor of CYP3A4 isoenzyme, when taken together with Vega Extra Cobra 130 Mg (50 mg) causes an increase in the concentration of Vega Extra in plasma by 56%.

A single dose of 100 mg of Vega Extra Cobra 130 Mg together with erythromycin (500 mg/day 2 times a day for 5 days), a moderate inhibitor of CYP3A4 isoenzyme, while achieving a constant concentration of erythromycin in the blood, leads to an increase in the AUC of Vega Extra Cobra 130 Mg by 182%.

When co-administered Vega Extra Cobra 130 Mg (once 100 mg) and saquinavir (1200 mg/day 3 times daily), an inhibitor of HIV protease and of CYP3A4, on the background to achieve a constant concentration of saquinavir in the blood, Cmax of Vega 120 Mg was increased by 140% and the AUC increased by 210%.

Stronger inhibitors of CYP3A4 isoenzyme, such as ketoconazole and Itraconazole, can cause more pronounced changes in the pharmacokinetics of Vega Extra Cobra 130 Mg.

The simultaneous use of Vega Extra Cobra (100 mg once) and ritonavir (500 mg 2 times a day), an inhibitor of HIV protease and a strong inhibitor of cytochrome P450, on the background to achieve a constant concentration of ritonavir in the blood leads to an increase in Cmax of Vega Extra Cobra 130 Mg by 300% (4 times), a AUC by 1000% (11-fold). After 24 h, the concentration of Vega Cobra 120 in blood plasma is about 200 ng/ml (after a single application of one Cobra Vega 120 Mg — 5 ng/ml). This is consistent with the ritonavir effect on a wide range of cytochrome P450 substrates. Vega Cobra 120 Mg does not affect the pharmacokinetics of ritonavir. Given these data, the simultaneous reception of ritonavir and Sildenafil Tablets Vegah Extra Cobra is not recommended. In any case, the maximum dose of Cobra Vega 120 Mg under any circumstances should not exceed 25 mg for 48 hours. If Vega Extra Cobra 130 Mg is taken in the recommended doses, patients receiving strong inhibitors of CYP3A4 isoenzyme at the same time, then Cmax free Vegah Extra 120 Mg does not exceed 200 nm, and the drug is well tolerated.

Single administration of antacid (magnesium hydroxide/aluminum hydroxide) does not affect the bioavailability of Vega Extra Cobra.

Studies involving healthy volunteers with simultaneous use of endothelin receptor antagonist, bosentan (CYP3A4 isoenzyme inducer (moderate), CYP2C9, and possibly CYP2C19) in Css (125 mg 2 times a day) and Sildenafil Vega Extra 130 in Css (80 mg 3 times a day) showed a decrease in AUC and Cmax Vega Extra Cobra by 62.6 and 52.4%, respectively. Vega Extra Cobra 130 Mg increased the AUC and Cmax of bosentan by 49.8 and 42%, respectively.

It is assumed that the simultaneous use of Vega Extra Cobra 130 Mg with powerful inducers of CYP3A4 isoenzyme, such as rifampicin, can lead to a greater decrease in the concentration of Sildenafil Vega Extra 130 in blood plasma.

CYP2D6 isoenzyme inhibitors (SSRIs, tricyclic antidepressants), thiazide and thiazide-like diuretics, ACE inhibitors and calcium antagonists have no effect on the pharmacokinetics of Vega Extra Cobra 130 Mg.

Azithromycin (500 mg/day for 3 days) has no effect on AUC, Cmax, Tmax, excretion rate constant and T1/2 Vega 120 Mg or its main circulating metabolite.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Cobra Vega Extra, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Vega Extra Strong 120 therapy in case of sudden loss of vision and consult a doctor immediately.

Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Vega Extra Cobra 130 Mg, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk. In patients with episodes of development PINZN with loss of vision in one eye receiving Vega Extra Cobra 130 Mg is contraindicated (see "Contraindications").

A small number of patients with hereditary retinitis pigmentosa have genetically determined disorders of the PDE of the retina. Information about the safety of the drug Vega Extra Cobra 130 Mg in patients with retinitis pigmentosa absent, so these patients should not be used Cobra Vega 120 (see "Contraindications").

Cardiovascular complications

During the post-marketing use of Vegah Extra 120 Mg for the treatment of erectile dysfunction, adverse events such as severe cardiovascular complications (including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, hemorrhagic stroke, transient ischemic attack, hypertension and hypotension) were reported, which had a temporary connection with the use of Vega Extra Cobra 130 Mg. Most of these patients, but not all of them, had risk factors for cardiovascular complications. Many of these adverse events were observed shortly after sexual activity, and some were observed after taking Vega Extra Cobra 130 Mg without subsequent sexual activity. It is not possible to establish a direct link between the reported adverse events and those or other factors.

Hypotension

Vega Extra Cobra 130 Mg has a systemic vasodilating effect, leading to a transient decrease in blood PRESSURE, which is not clinically significant and does not lead to any consequences in most patients. However, before prescribing Vega Extra Cobra 130 Mg, the doctor should carefully assess the risk of possible undesirable manifestations of vasodilating action in patients with relevant diseases, especially against the background of sexual activity. Increased susceptibility to vasodilators is observed in patients with obstruction of the output tract of the left ventricle (aortic stenosis, GOCMP), as well as with the rare syndrome of multiple systemic atrophy, manifested by a severe violation of the regulation of blood PRESSURE from the autonomic nervous system.

Since the combined use of Vega Extra Cobra 130 Mg and α-blockers can lead to symptomatic hypotension in some sensitive patients, Vega Extra Cobra 130 Mg should be used with caution in patients taking α-blockers (see "Interaction"). To minimize the risk of postural hypotension in patients taking α-blockers, the drug Vega Extra Cobra 130 Mg should be started only after achieving stabilization of hemodynamic parameters in these patients. It should also consider reducing the initial dose of Vega Extra Cobra 130 Mg (see. "Dosage and administration"). The doctor should inform patients about what actions should be taken in case of symptoms of postural hypotension.



Vega Extra Cobra

Reviews

Vega-extra87 out of100 with34 ratings
Vega-extraWe have no regrets! Buy this now.Rating:78 out of100, 70Vega-extraNot able to tell you how happy I am with Vega-extra. We've used Vega-extra for the last five years.Rating:93 out of100, 70Vega-extraVega-extra is exactly what our business has been lacking.Rating:97 out of100, 70Vega-extraThe very best. It's the perfect solution for our business. You guys rock! I STRONGLY recommend Vega-extra to EVERYONE interested in running a successful online business!Rating:82 out of100, 70Vega-extraIt really saves me time and effort. Vega-extra is exactly what our business has been lacking. I didn't even need training.Rating:89 out of100, 70Vega-extraVega-extra is the most valuable business resource we have EVER purchased. Really good.Rating:84 out of100, 70Vega-extraI would also like to say thank you to all your staff. I like Vega-extra more and more each day because it makes my life a lot easier. Since I invested in Vega-extra I made over 100,000 dollars profits.Rating:74 out of100, 70Vega-extraI love Vega-extra. Your company is truly upstanding and is behind its product 100%. We can't understand how we've been living without Vega-extra.Rating:79 out of100, 70Vega-extraIt's exactly what I've been looking for.Rating:72 out of100, 70Vega-extraI love your system. If you aren't sure, always go for Vega-extra. I STRONGLY recommend Vega-extra to EVERYONE interested in running a successful online business! If you want real marketing that works and effective implementation - Vega-extra's got you covered.Rating:90 out of100, 70Vega-extraNeedless to say we are extremely satisfied with the results. Keep up the excellent work.Rating:84 out of100, 70Vega-extraI will refer everyone I know. Man, this thing is getting better and better as I learn more about it.Rating:99 out of100, 70Vega-extraDefinitely worth the investment. Without Vega-extra, we would have gone bankrupt by now. If you want real marketing that works and effective implementation - Vega-extra's got you covered.Rating:89 out of100, 70Vega-extraBuy this now.Rating:88 out of100, 70Vega-extraI love your system. I could probably go into sales for you.Rating:96 out of100, 70Vega-extraVega-extra is awesome! You've saved our business!Rating:100 out of100, 70Vega-extraIf you aren't sure, always go for Vega-extra.Rating:95 out of100, 70Vega-extraI use Vega-extra often. Vega-extra saved my business. I will let my mum know about this, she could really make use of Vega-extra!Rating:70 out of100, 70Vega-extraYou've saved our business! We can't understand how we've been living without Vega-extra. It's really wonderful.Rating:83 out of100, 70Vega-extraI would also like to say thank you to all your staff. I like Vega-extra more and more each day because it makes my life a lot easier. Since I invested in Vega-extra I made over 100,000 dollars profits.Rating:95 out of100, 70Vega-extraIt's incredible. Since I invested in Vega-extra I made over 100,000 dollars profits. Vega-extra did exactly what you said it does.Rating:91 out of100, 70Vega-extraVega-extra is both attractive and highly adaptable.Rating:100 out of100, 70Vega-extraI will refer everyone I know. Man, this thing is getting better and better as I learn more about it.Rating:100 out of100, 70Vega-extraVega-extra has got everything I need.Rating:92 out of100, 70Vega-extraAbsolutely wonderful! I STRONGLY recommend Vega-extra to EVERYONE interested in running a successful online business! It fits our needs perfectly. We can't understand how we've been living without Vega-extra.Rating:73 out of100, 70Vega-extraThe service was excellent.Rating:71 out of100, 70Vega-extraThe very best.Rating:86 out of100, 70Vega-extraI would also like to say thank you to all your staff. We have no regrets!Rating:80 out of100, 70Vega-extraYour company is truly upstanding and is behind its product 100%.Rating:98 out of100, 70Vega-extraVega-extra is the next killer app. Keep up the excellent work. Absolutely wonderful!Rating:93 out of100, 70Vega-extraWow what great service, I love it! I use Vega-extra often.Rating:100 out of100, 70Vega-extraNeedless to say we are extremely satisfied with the results. Thank you for making it painless, pleasant and most of all hassle free! Vega-extra is exactly what our business has been lacking.Rating:77 out of100, 70Vega-extraVega-extra is the real deal! After using Vega-extra my business skyrocketed! I have gotten at least 50 times the value from Vega-extra.Rating:71 out of100, 70Vega-extraYou won't regret it. Vega-extra is exactly what our business has been lacking. I couldn't have asked for more than this. Nice work on your Vega-extra.Rating:81 out of100, 70

Our bestsellers