Home
Currency:USD
Language: en

ED RX Medications

0
You have no items in your shopping cart.

0

Currency: USD
Language: English

Welcome to our online pharmacy!

Vega Extra Cobra (sildenafil citrate)

Vega Extra Cobra (sildenafil citrate)

$ 1.02 per pill

Quick Overview

Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Sildenafil Vega Extra 130, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk. In patients with episodes of development PINZN with loss of vision in one eye receiving Sildenafil Vega Extra 130 is contraindicated (see "Contraindications").

Vega Extra Cobra® (Signature)

Vega Extra Cobra (Sildenafil citrate) 120 mg

Vega Extra Cobra
Sildenafil citrate
120 mg × 180 pills
$ 193.90 $ 183.95
$ 1.02 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 120 pills
$ 160.90 $ 151.95
$ 1.27 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 90 pills
$ 145.90 $ 137.95
$ 1.53 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 60 pills
$ 115.90 $ 109.95
$ 1.83 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 30 pills
$ 67.90 $ 63.95
$ 2.13 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 20 pills
$ 49.90 $ 46.95
$ 2.35 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 10 pills
$ 27.90 $ 25.95
$ 2.59 per pill
Buy

Information

Contraindications

hypersensitivity to Cobra Vega 120 Mg or any other component of the drug;

application in patients receiving constantly or intermittently nitric oxide donators, organic nitrates or nitrites in any form, as Vega 120 Mg enhances the hypotensive effect of nitrates (see "Interaction»);

the combined use of inhibitors of PDE5, including Sildenafil Tablets Vega Extra Cobra, called guanylate cyclase stimulants such as riociguat, because it can lead to symptomatic hypotension;

concomitant use with other agents for the treatment of erectile dysfunction (safety and efficacy of Sildenafil Vega Extra 130 when used together has not been studied (see. "Special instructions»);

lactose intolerance, lactase deficiency, glucose-papacosma malabsorption;

severe liver failure (class C classification for child-Pugh);

simultaneous administration of ritonavir;

severe cardiovascular diseases (severe heart failure, unstable angina, stroke or myocardial infarction during the last 6 months, life-threatening arrhythmias, hypertension (BP >170/100 mm Hg). art.) or hypotension (blood PRESSURE <90/50 mm Hg.art.) (see "Special instructions»);

patients with episodes of development partizanai anterior ischemic optic neuropathies (NESN) with loss of vision in one eye;

hereditary retinitis pigmentosa (see special instructions»);

according to the registered indication is not intended for use in women;

according to the registered indication is not intended for use in children under 18 years.

With caution: anatomic deformity of the penis (angulation, cavernous fibrosis or Peyronie's disease) (see "Special instructions"); diseases of, predisposing to the development of priapism (sickle-cell anemia, multiple myeloma, leukemia, thrombocythemia) (see "Special instructions"); diseases accompanied by haemorrhage; ulcer disease of stomach and duodenum in the acute phase; liver dysfunction; severe renal insufficiency (Cl creatinine <30 ml/min); patients with an episode of partizanai development of the anterior ischemic optic neuropathies in history (see "Special instructions); simultaneous reception of blockers α-adrenergic receptors.

Use during pregnancy and breast-feeding

According to the registered indication, the drug is not intended for use in women.

The pharmacokinetics of Sildenafil Vega Extra 130 in the recommended dose range is linear.

Suction. After intake of Vegab Extra is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Sildenafil Vega Extra 130 at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Sildenafil Vega Extra 120 100 mg average Cmax free Sildenafil Vega Extra 130 in plasma men is about 18 ng/ml (38 nm). Cmax when taking Sildenafil Vega Extra 130 inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Cobra Vega Extra is 105 l. the Association of Sildenafil Vega Extra 130 and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Sildenafil Vega Extra 130 (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Vegah Extra 120 Indication is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Sildenafil Vega Extra 130 Mg Cobra, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Cobra Vega Extra Strong 120 Mg, and its activity against PDE-5 in vitro is about 50% of the activity of Vegah Cobra. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Sildenafil Vega Extra 130. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Cobra Vega is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Vega Visa is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Sildenafil Vega Extra 130 is a potent selective inhibitor of cGMP-specific PDE-5.



Mechanism of action

The implementation of the physiological mechanism of erection is associated with the release of nitric oxide (NO) in the cavernous body during sexual stimulation. This, in turn, leads to an increase in the level of cGMP, the subsequent relaxation of smooth muscle tissue of the cavernous body and an increase in blood flow.

Vega Extra does not have a direct relaxing effect on the isolated cavernous human body, but enhances the effect of nitric oxide by inhibiting PDE-5, which is responsible for the disintegration of cGMP.

Selective Cobra Vega Extra Strong 120 Mg against PDE5 in vitro, its activity against PDE5 superior activity against other known PDE isoenzymes: PDE-6 — 10 times; PDE-1 more than 80 times; PDE-2, PDE-4, PDE-7 PDE–11 more than 700 times. Vega Extra is 4000 times more selective for PDE-5 than PDE-3, which is crucial because PDE-3 is one of the key enzymes in the regulation of myocardial contractility.

A prerequisite for the effectiveness of Sildenafil Vega Extra 130 is sexual stimulation.

Sildenafil Vega Extra 130 restores impaired erectile function in conditions of sexual stimulation by increasing blood flow to the cavernous bodies of the penis.

Clinical data

In a placebo-controlled cross-examination of patients with proven early age macular degeneration (n=9), Sildenafil Vega Extra 130 was well tolerated at a single dose of 100 mg. There were no clinically significant changes in vision evaluated by special visual tests (visual acuity, Amsler lattice, color perception, color simulation, Humphrey perimeter and photostress).

Efficiency. The efficacy and safety of Vega Extra Strong 120 were evaluated in 21 randomized double-blind placebo-controlled studies lasting up to 6 months in 3000 patients from 19 to 87 years with erectile dysfunction of different etiology (organic, psychogenic or mixed). The efficacy of the drug was evaluated globally using an erection diary, an international erectile function index (validated questionnaire on the state of sexual function) and a partner survey.

The effectiveness of Sildenafil Vega Extra 130, defined as the ability to achieve and maintain an erection sufficient for satisfactory sexual intercourse, has been demonstrated in all studies and confirmed in long-term studies lasting 1 year. In studies with the use of fixed-dose proportion of patients reporting that treatment improved their erections were 62% (dose of Vega Cobra 120 25 mg), 74% (dose Vega Cobra 120 50 mg) and 82% (dose Vega Extra 120 Mg 100 mg) compared to 25% in the placebo group. Analysis of the international index of erectile function showed that in addition to improving erection treatment Sildenafil Vega Extra 130 also increased the quality of orgasm, allowing to achieve satisfaction from sexual intercourse and overall satisfaction.

According to the generalized data, 59% of patients with diabetes, 43% of patients who underwent radical prostatectomy and 83% of patients with spinal cord injuries (against 16, 15 and 12% in the placebo group, respectively) were reported to have improved erection in the treatment of Cobra Vega Extra Strong 120 Mg.

Pharmacokinetics



Vega Cobra 120 Mg

Reviews

Vega-extra85 out of100 with45 ratings
Vega-extraThis is simply unbelievable! You won't regret it. We were treated like royalty.Rating:89 out of100, 71Vega-extraIt's just amazing.Rating:90 out of100, 71Vega-extraVega-extra should be nominated for service of the year. Keep up the excellent work. Thank you so much for your help.Rating:88 out of100, 71Vega-extraI am completely blown away.Rating:83 out of100, 71Vega-extraI couldn't have asked for more than this. Thanks Vega-extra! You guys rock!Rating:93 out of100, 71Vega-extraVega-extra is both attractive and highly adaptable. Vega-extra is great. Vega-extra has completely surpassed our expectations. The service was excellent.Rating:84 out of100, 71Vega-extraIt's just amazing. If you want real marketing that works and effective implementation - Vega-extra's got you covered. Thanks guys, keep up the good work!Rating:80 out of100, 71Vega-extraI love Vega-extra. Vega-extra is the most valuable business resource we have EVER purchased. Just what I was looking for.Rating:99 out of100, 71Vega-extraNot able to tell you how happy I am with Vega-extra. We've used Vega-extra for the last five years.Rating:95 out of100, 71Vega-extraBest. Product. Ever!Rating:89 out of100, 71Vega-extraI could probably go into sales for you. It's the perfect solution for our business. No matter where you go, Vega-extra is the coolest, most happening thing around!Rating:75 out of100, 71Vega-extraVega-extra saved my business. The service was excellent.Rating:80 out of100, 71Vega-extraI would gladly pay over 600 dollars for Vega-extra. If you want real marketing that works and effective implementation - Vega-extra's got you covered. Really good. Not able to tell you how happy I am with Vega-extra.Rating:93 out of100, 71Vega-extraI have gotten at least 50 times the value from Vega-extra. I can't say enough about Vega-extra. Vega-extra should be nominated for service of the year. We've used Vega-extra for the last five years.Rating:81 out of100, 71Vega-extraWe've seen amazing results already. It really saves me time and effort. Vega-extra is exactly what our business has been lacking. It's incredible. Vega-extra impressed me on multiple levels.Rating:90 out of100, 71Vega-extraVega-extra is worth much more than I paid.Rating:71 out of100, 71Vega-extraThank you so much for your help. I will refer everyone I know. I would be lost without Vega-extra.Rating:91 out of100, 71Vega-extraJust what I was looking for. Vega-extra was the best investment I ever made.Rating:75 out of100, 71Vega-extraVega-extra is both attractive and highly adaptable. I will refer everyone I know.Rating:87 out of100, 71Vega-extraI would also like to say thank you to all your staff. It fits our needs perfectly.Rating:71 out of100, 71Vega-extraVega-extra is worth much more than I paid.Rating:71 out of100, 71Vega-extraIt's really wonderful. Very easy to use. I can't say enough about Vega-extra.Rating:88 out of100, 71Vega-extraVega-extra was the best investment I ever made.Rating:74 out of100, 71Vega-extraNeedless to say we are extremely satisfied with the results. I have gotten at least 50 times the value from Vega-extra. Thank you for making it painless, pleasant and most of all hassle free!Rating:80 out of100, 71Vega-extraI am really satisfied with my Vega-extra. Vega-extra was worth a fortune to my company. Thank you for making it painless, pleasant and most of all hassle free! I couldn't have asked for more than this.Rating:97 out of100, 71Vega-extraI would also like to say thank you to all your staff. I am really satisfied with my Vega-extra. It's just amazing. Vega-extra is exactly what our business has been lacking.Rating:98 out of100, 71Vega-extraWe've seen amazing results already.Rating:79 out of100, 71Vega-extraThis is simply unbelievable! Vega-extra is the most valuable business resource we have EVER purchased. I just can't get enough of Vega-extra. I want to get a T-Shirt with Vega-extra on it so I can show it off to everyone.Rating:91 out of100, 71Vega-extraI love Vega-extra. Your company is truly upstanding and is behind its product 100%. We can't understand how we've been living without Vega-extra.Rating:95 out of100, 71Vega-extraI would also like to say thank you to all your staff. I like Vega-extra more and more each day because it makes my life a lot easier. Since I invested in Vega-extra I made over 100,000 dollars profits.Rating:71 out of100, 71Vega-extraVega-extra has got everything I need. Just what I was looking for.Rating:89 out of100, 71Vega-extraWe're loving it. Definitely worth the investment. I am really satisfied with my Vega-extra.Rating:83 out of100, 71Vega-extraAfter using Vega-extra my business skyrocketed! I could probably go into sales for you. Great job, I will definitely be ordering again! Vega-extra has completely surpassed our expectations.Rating:76 out of100, 71Vega-extraVega-extra was the best investment I ever made.Rating:71 out of100, 71Vega-extraVega-extra was the best investment I ever made.Rating:94 out of100, 71Vega-extraVega-extra is the most valuable business resource we have EVER purchased. Vega-extra is the most valuable business resource we have EVER purchased. It's all good. I would like to personally thank you for your outstanding product.Rating:86 out of100, 71Vega-extraIt's just amazing.Rating:82 out of100, 71Vega-extraI am really satisfied with my Vega-extra. Really good. I love Vega-extra.Rating:71 out of100, 71Vega-extraI have gotten at least 50 times the value from Vega-extra. Vega-extra has got everything I need. The very best. I like Vega-extra more and more each day because it makes my life a lot easier.Rating:93 out of100, 71Vega-extraYour company is truly upstanding and is behind its product 100%. No matter where you go, Vega-extra is the coolest, most happening thing around! I made back the purchase price in just 48 hours! I have gotten at least 50 times the value from Vega-extra.Rating:90 out of100, 71Vega-extraVega-extra saved my business. The service was excellent.Rating:100 out of100, 71Vega-extraIt's just amazing. Vega-extra is both attractive and highly adaptable. I would be lost without Vega-extra.Rating:85 out of100, 71Vega-extraThank you for making it painless, pleasant and most of all hassle free! I will refer everyone I know. Vega-extra should be nominated for service of the year.Rating:90 out of100, 71Vega-extraNeedless to say we are extremely satisfied with the results.Rating:82 out of100, 71Vega-extraI will refer everyone I know.Rating:77 out of100, 71

Our bestsellers