Home
Currency:USD
Language: en

ED RX Medications

0
You have no items in your shopping cart.

0

Currency: USD
Language: English

Welcome to our online pharmacy!

Vega Extra Cobra (sildenafil citrate)

Vega Extra Cobra (sildenafil citrate)

$ 1.02 per pill

Quick Overview

A single dose of 100 mg of Vega 120 Mg together with erythromycin (500 mg/day 2 times a day for 5 days), a moderate inhibitor of CYP3A4 isoenzyme, while achieving a constant concentration of erythromycin in the blood, leads to an increase in the AUC of Vega 120 Mg by 182%.

Vega Extra Cobra® (Signature)

Vega Extra Cobra (Sildenafil citrate) 120 mg

Vega Extra Cobra
Sildenafil citrate
120 mg × 180 pills
$ 193.90 $ 183.95
$ 1.02 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 120 pills
$ 160.90 $ 151.95
$ 1.27 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 90 pills
$ 145.90 $ 137.95
$ 1.53 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 60 pills
$ 115.90 $ 109.95
$ 1.83 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 30 pills
$ 67.90 $ 63.95
$ 2.13 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 20 pills
$ 49.90 $ 46.95
$ 2.35 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 10 pills
$ 27.90 $ 25.95
$ 2.59 per pill
Buy

Information

Hearing impairment

Some post-marketing and clinical studies have reported cases of sudden hearing loss or impairment associated with the use of all PDE-5 inhibitors, including Signature Cobra Vega. Most of these patients had risk factors for sudden impairment or hearing loss. There is no causal relationship between the use of PDE-5 inhibitors and sudden hearing impairment or hearing loss. In case of sudden hearing impairment or hearing loss while taking Vega Extra, consult a doctor immediately.

Bleedings

Cobra Vega 120 enhances the antiplatelet effect of sodium nitroprusside, a nitric oxide donator, on human platelets in vitro. Data on the safety of Vega Extra Strong 120 in patients with a tendency to bleeding or exacerbation of gastric ulcer and duodenal ulcer are not available, so the drug Sildenafil Vega Extra 130 in these patients should be used with caution (see With caution).

The incidence of nosebleeds in patients with pulmonary hypertension associated with diffuse connective tissue diseases was higher (Vegah Extra 130 — 12.9%, placebo — 0%) than in patients with primary pulmonary arterial hypertension (Sildenafil Vega Extra 130 — 3%, placebo — 2.4%). Patients receiving Vega Extra Cobra 120 in combination with an antagonist of vitamin K, the frequency of nasal bleeding was higher (8.8 percent) than patients who were not taking an antagonist of vitamin K (1.7 percent).

Use in conjunction with other means for the treatment of erectile dysfunction

The safety and efficacy of Extra Vega together with other PDE-5 inhibitors or other drugs for the treatment of pulmonary hypertension containing Sildenafil Vega Extra 130 Mg Cobra (eg, Revatsio®), or other means for the treatment of erection disorders have not been studied, so the use of such combinations is not recommended (see "Contraindications").

Influence on the ability to drive and mechanisms. In patients receiving Sildenafil Vega Extra 130 any negative effect on the ability to drive a car or other means was not observed. However, since when taking Sildenafil Vega Extra 130 may develop dizziness, lowering blood PRESSURE, the development of chromatopsia, blurred vision, etc. side effects, care should be taken when driving and doing other potentially dangerous activities that require increased concentration and speed of psychomotor reactions. Also, you should be careful about the individual action of the drug in these situations, especially at the beginning of treatment and when changing the dosage regimen.

The pharmacokinetics of Sildenafil Vega Extra 130 in the recommended dose range is linear.

Suction. After intake of Cobra Vega Extra is rapidly absorbed. Absolute bioavailability averages about 40% (25 to 63%). In vitro Vega Visa at a concentration of about 1.7 ng/ml (3.5 nm) inhibits the activity of PDE-5 50%. After a single dose of Sildenafil Vega Extra 130 100 mg average Cmax free Sildenafil Vega Extra 130 in plasma men is about 18 ng/ml (38 nm). Cmax when taking Sildenafil Vega Extra 130 inside fasting is achieved for an average of 60 minutes (from 30 to 120 minutes). When taken in combination with fatty foods, the rate of absorption decreases: Cmax decreases by an average of 29%, and Tmax increases by 60 minutes, but the degree of absorption does not change significantly (AUC decreases by 11%).

Distribution. The average Vss of Sildenafil Vega Extra 130 is 105 l. the Association of Sildenafil Vega Extra 130 and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Sildenafil Vega Extra 130 (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Metabolism. Sildenafil Vega Extra 130 is metabolized mainly in the liver by the action of CYP3A4 isoenzyme (main pathway) and CYP2C9 isoenzyme (minor pathway). The main circulating active metabolite, formed as a result of N-demethylation of Vegah Extra 130, undergoes further metabolism. The selectivity of this metabolite against PDE is comparable to that of Sildenafil Vega Extra 130, and its activity against PDE-5 in vitro is about 50% of the activity of Vegah Cobra. The concentration of the metabolite in the blood plasma of healthy volunteers was about 40% of the concentration of Vega Extra Cobra 130 Mg. N-demethyl metabolite undergoes further metabolism; its T1/2 is about 4 no.

Breeding. The total clearance of Vegah Extra 120 Indication is 41 l/h, and the final T1/2 — 3-5 h. After oral administration, as well as after I/V, Vegah Extra 120 Indication is excreted as metabolites, mainly by the intestine (about 80% oral dose) and to a lesser extent by the kidneys (about 13% oral dose).

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Vegah Extra 130, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Sildenafil Vega Extra 130 Mg therapy in case of sudden loss of vision and consult a doctor immediately.

Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Sildenafil Vega Extra 130, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk. In patients with episodes of development PINZN with loss of vision in one eye receiving Sildenafil Vega Extra 130 is contraindicated (see "Contraindications").

A small number of patients with hereditary retinitis pigmentosa have genetically determined disorders of the PDE of the retina. Information about the safety of the drug Sildenafil Vega Extra 130 in patients with retinitis pigmentosa absent, so these patients should not be used Sildenafil Vega Extra 130 (see "Contraindications").

Cardiovascular complications

During the post-marketing use of Sildenafil Vega Extra 130 for the treatment of erectile dysfunction, adverse events such as severe cardiovascular complications (including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, hemorrhagic stroke, transient ischemic attack, hypertension and hypotension) were reported, which had a temporary connection with the use of Vega Extra Strong 120. Most of these patients, but not all of them, had risk factors for cardiovascular complications. Many of these adverse events were observed shortly after sexual activity, and some were observed after taking Vega Extra Strong 120 without subsequent sexual activity. It is not possible to establish a direct link between the reported adverse events and those or other factors.

Visual impairment

In rare cases, during post-approval use of all of the inhibitors of PDE5, including Sildenafil Vega Extra 130, reported NESN is a rare disease and the cause of the decrease or loss of vision. Most of these patients had risk factors, such as decreased ratios of excavation diameter to optic disc (stagnant disc), age over 50, diabetes, hypertension, CHD, hyperlipidemia, and Smoking. In an observational study evaluated whether recent use of drugs class of inhibitors PDE-5 with an acute onset NESN. The results indicate approximately a 2-fold increase in risk of developing NESN within 5T1/2 after application of the PDE-5 inhibitor. According to published literature, the annual incidence of npins IS 2.5–11.8 cases per 100,000 men aged ≥50 years in the General population. Patients should be advised to stop Vegab Extra therapy in case of sudden loss of vision and consult a doctor immediately. Persons who have already had a case NESN have an increased risk of relapse NESN. Therefore, the doctor should discuss this risk with such patients, as well as the potential chance of adverse effects of PDE-5 inhibitors. PDE-5 inhibitors, including Cobra 120 Vega Extra, in such patients should be used with caution and only in situations where the expected benefit outweighs the risk.

When using the drug Vega Cobra in doses exceeding the recommended, adverse events were similar to those noted above, but usually more common.

*Side effects identified during post-marketing studies.

Interaction

Effect of other drugs on the pharmacokinetics of Cobra Vega Extra Strong 120mg

The metabolism of Sildenafil Vega Extra 130 occurs mainly under the action of CYP3A4 isoenzyme (main pathway), so inhibitors of this isoenzyme can reduce the clearance of Vega Extra Cobra 130 Mg, and inducers, respectively, increase the clearance of Signature Cobra Vega. A decrease in the clearance of Sildenafil Vega Extra 130 Mg with simultaneous use of inhibitors of CYP3A4 isoenzyme (ketoconazole, erythromycin, cimetidine).

Cimetidine (800 mg), a nonspecific inhibitor of CYP3A4 isoenzyme, when taken together with Sildenafil Vega Extra 130 Mg (50 mg) causes an increase in the concentration of Sildenafil Vega Extra 130 in plasma by 56%.

A single dose of 100 mg of Vega Extra Strong 120 together with erythromycin (500 mg/day 2 times a day for 5 days), a moderate inhibitor of CYP3A4 isoenzyme, while achieving a constant concentration of erythromycin in the blood, leads to an increase in the AUC of Vega Extra Cobra 120 by 182%.

When co-administered Sildenafil Vega Extra 130 (once 100 mg) and saquinavir (1200 mg/day 3 times daily), an inhibitor of HIV protease and of CYP3A4, on the background to achieve a constant concentration of saquinavir in the blood, Cmax of Sildenafil Vega Extra 130 was increased by 140% and the AUC increased by 210%.

Stronger inhibitors of CYP3A4 isoenzyme, such as ketoconazole and Itraconazole, can cause more pronounced changes in the pharmacokinetics of Sildenafil Vega Extra 120.

The simultaneous use of Vega Extra Cobra (100 mg once) and ritonavir (500 mg 2 times a day), an inhibitor of HIV protease and a strong inhibitor of cytochrome P450, on the background to achieve a constant concentration of ritonavir in the blood leads to an increase in Cmax of Sildenafil Vega Extra 120 by 300% (4 times), a AUC by 1000% (11-fold). After 24 h, the concentration of Sildenafil Vega Extra 130 in blood plasma is about 200 ng/ml (after a single application of one Vega Cobra 120 — 5 ng/ml). This is consistent with the ritonavir effect on a wide range of cytochrome P450 substrates. Sildenafil Vega Extra 130 does not affect the pharmacokinetics of ritonavir. Given these data, the simultaneous reception of ritonavir and Cobra Vega Extra Strong 120 Mg is not recommended. In any case, the maximum dose of Vega Extra 120 under any circumstances should not exceed 25 mg for 48 hours. If Sildenafil Vega Extra 130 is taken in the recommended doses, patients receiving strong inhibitors of CYP3A4 isoenzyme at the same time, then Cmax free Vega Extra Strong 120 does not exceed 200 nm, and the drug is well tolerated.

Single administration of antacid (magnesium hydroxide/aluminum hydroxide) does not affect the bioavailability of Sildenafil Vega Extra 130.

Studies involving healthy volunteers with simultaneous use of endothelin receptor antagonist, bosentan (CYP3A4 isoenzyme inducer (moderate), CYP2C9, and possibly CYP2C19) in Css (125 mg 2 times a day) and Sildenafil Tablets Vega Extra Cobra in Css (80 mg 3 times a day) showed a decrease in AUC and Cmax Vega Cobra 120 Mg by 62.6 and 52.4%, respectively. Sildenafil Vega Extra 130 increased the AUC and Cmax of bosentan by 49.8 and 42%, respectively.

It is assumed that the simultaneous use of Vega Extra Strong 120 with powerful inducers of CYP3A4 isoenzyme, such as rifampicin, can lead to a greater decrease in the concentration of Sildenafil Vega Extra 130 Mg in blood plasma.

CYP2D6 isoenzyme inhibitors (SSRIs, tricyclic antidepressants), thiazide and thiazide-like diuretics, ACE inhibitors and calcium antagonists have no effect on the pharmacokinetics of Sildenafil Vega Extra 130.

Azithromycin (500 mg/day for 3 days) has no effect on AUC, Cmax, Tmax, excretion rate constant and T1/2 Vega Extra or its main circulating metabolite.



Vega 120 Mg

Reviews

Vega-extra87 out of100 with44 ratings
Vega-extraI just can't get enough of Vega-extra. I want to get a T-Shirt with Vega-extra on it so I can show it off to everyone. We've seen amazing results already. Thanks to Vega-extra, we've just launched our 5th website! I just can't get enough of Vega-extra. I want to get a T-Shirt with Vega-extra on it so I can show it off to everyone.Rating:81 out of100, 70Vega-extraNeedless to say we are extremely satisfied with the results. I have gotten at least 50 times the value from Vega-extra. Thank you for making it painless, pleasant and most of all hassle free!Rating:80 out of100, 70Vega-extraI am completely blown away. I wish I would have thought of it first. You won't regret it. It really saves me time and effort. Vega-extra is exactly what our business has been lacking.Rating:73 out of100, 70Vega-extraIt's incredible. Since I invested in Vega-extra I made over 100,000 dollars profits. Vega-extra did exactly what you said it does.Rating:99 out of100, 70Vega-extraI will refer everyone I know.Rating:82 out of100, 70Vega-extraMan, this thing is getting better and better as I learn more about it. I was amazed at the quality of Vega-extra.Rating:86 out of100, 70Vega-extraI didn't even need training. Vega-extra impressed me on multiple levels. I could probably go into sales for you. Absolutely wonderful!Rating:91 out of100, 70Vega-extraVega-extra is both attractive and highly adaptable. You won't regret it.Rating:82 out of100, 70Vega-extraWe have no regrets! If you aren't sure, always go for Vega-extra. Vega-extra is the most valuable business resource we have EVER purchased.Rating:86 out of100, 70Vega-extraIf you aren't sure, always go for Vega-extra.Rating:74 out of100, 70Vega-extraNice work on your Vega-extra.Rating:93 out of100, 70Vega-extraWe have no regrets! If you want real marketing that works and effective implementation - Vega-extra's got you covered. Vega-extra is awesome!Rating:85 out of100, 70Vega-extraI couldn't have asked for more than this. Since I invested in Vega-extra I made over 100,000 dollars profits. I love your system.Rating:79 out of100, 70Vega-extraI'm good to go. Vega-extra is the next killer app.Rating:86 out of100, 70Vega-extraI would also like to say thank you to all your staff. I am really satisfied with my Vega-extra. It's just amazing. Vega-extra is exactly what our business has been lacking.Rating:100 out of100, 70Vega-extraDefinitely worth the investment.Rating:95 out of100, 70Vega-extraYou won't regret it. It really saves me time and effort. Vega-extra is exactly what our business has been lacking. I would also like to say thank you to all your staff. Vega-extra is exactly what our business has been lacking.Rating:81 out of100, 70Vega-extraVega-extra is the next killer app. I don't know what else to say. Man, this thing is getting better and better as I learn more about it. It's just amazing.Rating:89 out of100, 70Vega-extraWe've seen amazing results already.Rating:100 out of100, 70Vega-extraIt really saves me time and effort. Vega-extra is exactly what our business has been lacking. We've used Vega-extra for the last five years. I would also like to say thank you to all your staff. Vega-extra saved my business.Rating:91 out of100, 70Vega-extraNeedless to say we are extremely satisfied with the results.Rating:83 out of100, 70Vega-extraThanks to Vega-extra, we've just launched our 5th website! I would like to personally thank you for your outstanding product. This is simply unbelievable! I can't say enough about Vega-extra.Rating:83 out of100, 70Vega-extraI have gotten at least 50 times the value from Vega-extra.Rating:90 out of100, 70Vega-extraVega-extra has completely surpassed our expectations. Vega-extra is both attractive and highly adaptable. It really saves me time and effort. Vega-extra is exactly what our business has been lacking. I couldn't have asked for more than this.Rating:86 out of100, 70Vega-extraI would be lost without Vega-extra. I would also like to say thank you to all your staff.Rating:98 out of100, 70Vega-extraVega-extra is the real deal! Thanks Vega-extra!Rating:96 out of100, 70Vega-extraI didn't even need training. Vega-extra impressed me on multiple levels. I could probably go into sales for you. Absolutely wonderful!Rating:89 out of100, 70Vega-extraIt's just amazing. I made back the purchase price in just 48 hours! It's incredible. The best on the net!Rating:95 out of100, 70Vega-extraVega-extra is exactly what our business has been lacking. It's just amazing. I will recommend you to my colleagues.Rating:92 out of100, 70Vega-extraIt's just amazing. If you want real marketing that works and effective implementation - Vega-extra's got you covered. Thanks guys, keep up the good work!Rating:91 out of100, 70Vega-extraI would be lost without Vega-extra.Rating:99 out of100, 70Vega-extraIt fits our needs perfectly. I would like to personally thank you for your outstanding product. The very best.Rating:95 out of100, 70Vega-extraI am really satisfied with my Vega-extra. We've seen amazing results already. It's all good. Buy this now.Rating:88 out of100, 70Vega-extraI like Vega-extra more and more each day because it makes my life a lot easier. Your company is truly upstanding and is behind its product 100%.Rating:79 out of100, 70Vega-extraWe can't understand how we've been living without Vega-extra. Dude, your stuff is the bomb!Rating:71 out of100, 70Vega-extraNo matter where you go, Vega-extra is the coolest, most happening thing around! I just can't get enough of Vega-extra. I want to get a T-Shirt with Vega-extra on it so I can show it off to everyone. Best. Product. Ever! We've used Vega-extra for the last five years.Rating:96 out of100, 70Vega-extraYour company is truly upstanding and is behind its product 100%. Wow what great service, I love it!Rating:86 out of100, 70Vega-extraI don't know what else to say. Just what I was looking for. Your company is truly upstanding and is behind its product 100%.Rating:80 out of100, 70Vega-extraI would gladly pay over 600 dollars for Vega-extra.Rating:78 out of100, 70Vega-extraI just can't get enough of Vega-extra. I want to get a T-Shirt with Vega-extra on it so I can show it off to everyone. Very easy to use.Rating:74 out of100, 70Vega-extraIt fits our needs perfectly.Rating:71 out of100, 70Vega-extraYou won't regret it.Rating:100 out of100, 70Vega-extraI have gotten at least 50 times the value from Vega-extra. The best on the net!Rating:70 out of100, 70Vega-extraThanks to Vega-extra, we've just launched our 5th website! I STRONGLY recommend Vega-extra to EVERYONE interested in running a successful online business!Rating:85 out of100, 70

Our bestsellers