Home
Currency:USD
Language: en

ED RX Medications

0
You have no items in your shopping cart.

0

Currency: USD
Language: English

Welcome to our online pharmacy!

Vega Extra Cobra (sildenafil citrate)

Vega Extra Cobra (sildenafil citrate)

$ 1.02 per pill

Quick Overview

The average Vss of Vegal Extra is 105 l. the Association of Vegal Extra and its main circulating N-demethyl metabolite with plasma proteins is about 96% and does not depend on the total concentration of the drug. Less than 0.0002% of the dose of Vegal Extra (an average of 188 ng) was found in sperm 90 minutes after taking the drug.

Vega Extra Cobra® (Signature)

Vega Extra Cobra (Sildenafil citrate) 120 mg

Vega Extra Cobra
Sildenafil citrate
120 mg × 180 pills
$ 193.90 $ 183.95
$ 1.02 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 120 pills
$ 160.90 $ 151.95
$ 1.27 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 90 pills
$ 145.90 $ 137.95
$ 1.53 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 60 pills
$ 115.90 $ 109.95
$ 1.83 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 30 pills
$ 67.90 $ 63.95
$ 2.13 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 20 pills
$ 49.90 $ 46.95
$ 2.35 per pill
Buy
Vega Extra Cobra
Sildenafil citrate
120 mg × 10 pills
$ 27.90 $ 25.95
$ 2.59 per pill
Buy

Information

Contraindications

hypersensitivity to Vega Extra or any other component of the drug;

application in patients receiving constantly or intermittently nitric oxide donators, organic nitrates or nitrites in any form, as Vega 120 Mg enhances the hypotensive effect of nitrates (see "Interaction»);

the combined use of inhibitors of PDE5, including Cobra Vega 120 Mg, called guanylate cyclase stimulants such as riociguat, because it can lead to symptomatic hypotension;

concomitant use with other agents for the treatment of erectile dysfunction (safety and efficacy of Vegah Cobra when used together has not been studied (see. "Special instructions»);

lactose intolerance, lactase deficiency, glucose-papacosma malabsorption;

severe liver failure (class C classification for child-Pugh);

simultaneous administration of ritonavir;

severe cardiovascular diseases (severe heart failure, unstable angina, stroke or myocardial infarction during the last 6 months, life-threatening arrhythmias, hypertension (BP >170/100 mm Hg). art.) or hypotension (blood PRESSURE <90/50 mm Hg.art.) (see "Special instructions»);

patients with episodes of development partizanai anterior ischemic optic neuropathies (NESN) with loss of vision in one eye;

hereditary retinitis pigmentosa (see special instructions»);

according to the registered indication is not intended for use in women;

according to the registered indication is not intended for use in children under 18 years.

With caution: anatomic deformity of the penis (angulation, cavernous fibrosis or Peyronie's disease) (see "Special instructions"); diseases of, predisposing to the development of priapism (sickle-cell anemia, multiple myeloma, leukemia, thrombocythemia) (see "Special instructions"); diseases accompanied by haemorrhage; ulcer disease of stomach and duodenum in the acute phase; liver dysfunction; severe renal insufficiency (Cl creatinine <30 ml/min); patients with an episode of partizanai development of the anterior ischemic optic neuropathies in history (see "Special instructions); simultaneous reception of blockers α-adrenergic receptors.

Use during pregnancy and breast-feeding

According to the registered indication, the drug is not intended for use in women.

Influence of Vegal Extra on other drugs

Vegah Cobra is a weak inhibitor of cytochrome P450 — 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 ISOENZYMES (IC50 >150 µmol). When taking Sildenafil Tablets Vega Extra Cobra in recommended doses, its Cmax is about 1 µmol, so it is unlikely that Vegab Extra can affect the clearance of the substrates of these isoenzymes.

Sildenafil Vega Extra 130 increases the hypotensive effect of nitrates both with long-term use of the latter, and with their appointment for urgent indications. In this regard, the use of Vega Extra Cobra in combination with nitrates or nitric oxide donators is contraindicated. While taking α-adrenoblocker doxazosin (4 and 8 mg) and Vegah Extra 120 Mg (25, 50 and 100 mg) in patients with benign prostate hyperplasia with stable hemodynamics, the average additional decrease in sad/dad in the supine position was 7/7, 9/5 and 8/4 mm Hg.article, respectively, while in the standing position — 6/6, 11/4 mmHg, and 4/5.art. respectively. Reported rare cases of symptomatic postural hypotension in such patients, manifested in the form of dizziness (without fainting). In some sensitive patients receiving α-blockers, simultaneous use of Vega Extra can lead to symptomatic hypotension.

There were no signs of significant interaction with tolbutamide (250 mg) or warfarin (40 mg), which are metabolized by CYP2C9 isoenzyme.

Vegal Extra (100 mg) has no effect on the pharmacokinetics of the HIV protease inhibitor, saquinavir, which is a substrate of CYP3A4 isoenzyme, at its constant level in the blood.

The simultaneous use of Vega Extra Cobra at equilibrium (80 mg 3 times a day) leads to an increase in the AUC and Cmax of bosentan (125 mg 2 times a day) by 49.8 and 42%, respectively.

Vegal Extra (50 mg) does not cause an additional increase in bleeding time when taking acetylsalicylic acid (150 mg).

Vegal Extra (50 mg) does not increase the hypotensive effect of alcohol in healthy volunteers with Cmax of alcohol in the blood on average 0.08‰ (80 mg/DL).

In patients with hypertension, no signs of interaction of Vegal Extra (100 mg) with amlodipine were found. The average additional reduction in blood PRESSURE in the supine position is 8 mm Hg.V. (systolic) and 7 mm Hg.V. (diastolic).

The use of Sildenafil Vega Extra 120 in combination with antihypertensive agents does not lead to additional side effects.

Side effect

The most common side effects were headache and tides.

Usually the side effects of Vegal Extra are mild or moderate and are transient.

Studies using a fixed dose have shown that the frequency of some adverse events increases with increasing dose.

The frequency of adverse reactions is presented in the following classification: very often — ≥10%; often — ≥1% and <10%; infrequently — ≥0.1% and <1%; rarely — ≥0.01% and <0.1%; very rarely — <0.01%; frequency unknown — cannot be determined based on available data.

Co side of the immune system: infrequently — hypersensitivity reactions (including skin rash), allergic reactions.

On the part of the organ of vision: often — blurred vision, blurred vision, cyanopsia; rarely, eye pain, photophobia, photopsia, chromatopsia, eye redness/injection of the sclera, changing the brightness of cvetovete, mydriasis, conjunctivitis, hemorrhage in the tissue of the eye, cataract, a disorder of the lacrimal apparatus; rarely — swelling of the eyelids and adjacent tissues, a feeling of dryness in the eyes, the presence of iridescent circles in the field of view around the light source, increased fatigue of the eyes, vision of objects in yellow (xanthopsia), vision of objects in red (erythropsia), conjunctival hyperemia, irritation of the mucous membrane of the eyes, unpleasant sensations in the eyes; the frequency is unknown — NPINZN, occlusion of retinal veins, visual field defect, diplopia*, temporary vision loss or decreased visual acuity, increased IHD, edema retina, retinal vascular disease, vitreous detachment/vitreal traction.

On the part of the organ of hearing: infrequent — a sudden decrease or loss of hearing, tinnitus, pain in the ears.

From the CCC: often — tides; infrequently — tachycardia, palpitations, decreased blood PRESSURE, increased heart rate, unstable angina, AV-blockade, myocardial infarction, cerebral thrombosis, cardiac arrest, heart failure, deviations in ECG readings, cardiomyopathy; rarely — atrial fibrillation, sudden cardiac death*, ventricular arrhythmia*.

The blood and lymphatic system: rarely — anemia, leukopenia.

On the part of metabolism and nutrition: infrequently — a feeling of thirst, swelling, gout, uncompensated diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemia, hypernatremia.

From the respiratory system: often — nasal congestion; infrequent — nosebleeds, rhinitis, asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, increased volume of sputum, increased cough; rarely — a feeling of tightness in the throat, dryness of the nasal mucosa, swelling of the nasal mucosa.

From the digestive tract: often — nausea, dyspepsia; uncommon — GERD, vomiting, pain in the abdomen, dryness of the mucous membrane of the mouth, glossitis, gingivitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis, stomatitis, rejection of liver function tests from normal, rectal bleeding; rarely, hypesthesia of the mucous membrane of the oral cavity.

On the part of the musculoskeletal system: often — back pain; infrequently — myalgia, pain in the limbs, arthritis, arthrosis, tendon rupture, tenosynovitis, bone pain, myasthenia gravis, synovitis.

From the genitourinary system: infrequently — cystitis, nicturia, breast enlargement, urinary incontinence, hematuria, ejaculation disorders, genital edema, anorgasmia, hematospermia, damage to the tissues of the penis; rarely — prolonged erection and/or priapism.

From the Central and peripheral nervous system: very often — headache; often — dizziness; infrequently — drowsiness, migraine, ataxia, hypertension, neuralgia, neuropathy, paresthesia, tremor, vertigo, symptoms of depression, insomnia, unusual dreams, increased reflexes, hypesthesia; rarely — convulsions*, repeated convulsions*, fainting.

On the part of the skin and subcutaneous tissues: infrequently — skin rash, urticaria, herpes simplex, itching, sweating, skin ulceration, contact dermatitis, exfoliative dermatitis; the frequency is unknown — Stevens-Johnson syndrome, toxic epidermal necrolysis.

Other: infrequently — a feeling of heat, swelling of the face, photosensitivity reaction, shock, asthenia, fatigue, pain of various localization, chills, accidental falls, chest pain, accidental injuries; rarely — irritability.

Dosage and administration

Inside, can be taken with or without water. When taking the drug, you should put a tablet, dispersed in the oral cavity, on the tongue, after which it will quickly dissolve, and it can be swallowed. The tablet should be taken immediately after opening the blister. Patients who are recommended a dose of Sildenafil Vega Extra 130 Mg Cobra 100 mg, the second tablet of Vegal Extra 50 mg should be taken after complete dissolution of the first tablet.

The recommended dose for most adult patients is 50 mg approximately 1 hour before sexual activity. Taking into account the effectiveness and tolerability of the dose can be increased to 100 mg or reduced to 25 mg (only tablets coated with a film, the appropriate dosage). The maximum recommended dose is 100 mg. Patients who are recommended a dose of Vegal Extra 100 mg, it is necessary to take 2 table., dispersible in the oral cavity, dosage 50 mg consecutively one after another. The maximum recommended frequency of use — 1 time per day. It should be borne in mind that the absorption of Vegal Extra significantly slows down when used in combination with fatty foods.

Special patient groups

Renal impairment. In mild to moderate renal failure dose adjustment is not required, in severe renal failure (Creatinine CL <30 ml/min) Vegal Extra dose should be reduced to 25 mg.

Hepatic impairment. Since the excretion of Vegal Extra is disturbed in patients with liver damage (in particular, cirrhosis), the dose of Vegal Extra should be reduced to 25 mg.

Joint application with other drugs. Joint use with ritonavir is not recommended. In any case, the maximum dose of Cobra Vega 120 under any circumstances should not exceed 25 mg, and the frequency of application — 1 time in 48 h (see "Interaction").

When combined with inhibitors of CYP3A4 isoenzyme (erythromycin, saquinavir, ketoconazole, Itraconazole), the initial dose of Vegal Extra should be 25 mg (see "Interaction").

To minimize the risk of postural hypotension in patients taking α-blockers, Cobra Vega 120 should be started only after achieving hemodynamic stabilization in these patients. Consideration should also be given to reducing the initial dose of Vega Extra Strong 120 (see special instructions and Interactions).

Old age. Adjustment of the dose of Vega Extra Cobra 130 Mg is not required.



Cobra Vega 120 Mg

Reviews

Vega-extra85 out of100 with41 ratings
Vega-extraI was amazed at the quality of Vega-extra. If you want real marketing that works and effective implementation - Vega-extra's got you covered.Rating:80 out of100, 70Vega-extraIf you aren't sure, always go for Vega-extra.Rating:84 out of100, 70Vega-extraIt's incredible. I could probably go into sales for you. I'm good to go.Rating:83 out of100, 70Vega-extraIt's really wonderful.Rating:92 out of100, 70Vega-extraWe've used Vega-extra for the last five years. We can't understand how we've been living without Vega-extra. I couldn't have asked for more than this. I like Vega-extra more and more each day because it makes my life a lot easier.Rating:77 out of100, 70Vega-extraVega-extra did exactly what you said it does. I am so pleased with this product.Rating:70 out of100, 70Vega-extraWe were treated like royalty.Rating:89 out of100, 70Vega-extraIt's really wonderful.Rating:87 out of100, 70Vega-extraNice work on your Vega-extra. You guys rock! Your company is truly upstanding and is behind its product 100%. Vega-extra saved my business.Rating:90 out of100, 70Vega-extraIt's really wonderful.Rating:75 out of100, 70Vega-extra Vega-extra is the most valuable business resource we have EVER purchased. Vega-extra did exactly what you said it does. Vega-extra should be nominated for service of the year.Rating:96 out of100, 70Vega-extraI will refer everyone I know. You've saved our business! Definitely worth the investment. Vega-extra impressed me on multiple levels.Rating:87 out of100, 70Vega-extraI have gotten at least 50 times the value from Vega-extra. Vega-extra has completely surpassed our expectations. Definitely worth the investment.Rating:90 out of100, 70Vega-extraVery easy to use. Thanks Vega-extra!Rating:95 out of100, 70Vega-extraYou won't regret it.Rating:90 out of100, 70Vega-extraVega-extra is worth much more than I paid.Rating:82 out of100, 70Vega-extraVega-extra impressed me on multiple levels. Vega-extra has got everything I need. I'd be lost without Vega-extra.Rating:78 out of100, 70Vega-extraI love your system. We were treated like royalty. Vega-extra is worth much more than I paid. Thanks to Vega-extra, we've just launched our 5th website!Rating:85 out of100, 70Vega-extraYou've saved our business!Rating:83 out of100, 70Vega-extraI don't know what else to say. It's all good. I would gladly pay over 600 dollars for Vega-extra. I would also like to say thank you to all your staff.Rating:73 out of100, 70Vega-extraWe have no regrets! If you want real marketing that works and effective implementation - Vega-extra's got you covered. Vega-extra is awesome!Rating:81 out of100, 70Vega-extraThanks guys, keep up the good work! Vega-extra did exactly what you said it does. Vega-extra saved my business.Rating:72 out of100, 70Vega-extraVega-extra is exactly what our business has been lacking. I would gladly pay over 600 dollars for Vega-extra. It's really wonderful. It's really wonderful.Rating:72 out of100, 70Vega-extraKeep up the excellent work. Not able to tell you how happy I am with Vega-extra.Rating:93 out of100, 70Vega-extraIt's just amazing. It really saves me time and effort. Vega-extra is exactly what our business has been lacking. Vega-extra is the next killer app. Thanks to Vega-extra, we've just launched our 5th website!Rating:77 out of100, 70Vega-extraDefinitely worth the investment.Rating:89 out of100, 70Vega-extraWe can't understand how we've been living without Vega-extra. You won't regret it. I don't know what else to say. Vega-extra is great.Rating:81 out of100, 70Vega-extraWe're loving it. I'm good to go. It really saves me time and effort. Vega-extra is exactly what our business has been lacking. You've saved our business!Rating:86 out of100, 70Vega-extraGreat job, I will definitely be ordering again! Vega-extra is both attractive and highly adaptable. I will let my mum know about this, she could really make use of Vega-extra!Rating:86 out of100, 70Vega-extraI was amazed at the quality of Vega-extra.Rating:89 out of100, 70Vega-extraWe were treated like royalty.Rating:90 out of100, 70Vega-extraVega-extra has really helped our business. I would like to personally thank you for your outstanding product. I'd be lost without Vega-extra.Rating:93 out of100, 70Vega-extraAfter using Vega-extra my business skyrocketed! I just can't get enough of Vega-extra. I want to get a T-Shirt with Vega-extra on it so I can show it off to everyone.Rating:94 out of100, 70Vega-extraBuy this now. Vega-extra is the most valuable business resource we have EVER purchased.Rating:91 out of100, 70Vega-extraI have gotten at least 50 times the value from Vega-extra. If you want real marketing that works and effective implementation - Vega-extra's got you covered. It's the perfect solution for our business.Rating:75 out of100, 70Vega-extraThe very best. Vega-extra is exactly what our business has been lacking. I would like to personally thank you for your outstanding product.Rating:98 out of100, 70Vega-extraI like Vega-extra more and more each day because it makes my life a lot easier. Vega-extra is the real deal! It's incredible. Vega-extra is worth much more than I paid.Rating:94 out of100, 70Vega-extraAbsolutely wonderful! Dude, your stuff is the bomb!Rating:74 out of100, 70Vega-extraSince I invested in Vega-extra I made over 100,000 dollars profits. Best. Product. Ever!Rating:90 out of100, 70Vega-extraYou guys rock! Vega-extra is the most valuable business resource we have EVER purchased.Rating:97 out of100, 70Vega-extraIt's really wonderful.Rating:96 out of100, 70

Our bestsellers